Merck
  • Home
  • Search Results
  • A polysaccharide from Salvia miltiorrhiza Bunge improves immune function in gastric cancer rats.

A polysaccharide from Salvia miltiorrhiza Bunge improves immune function in gastric cancer rats.

Carbohydrate polymers (2014-07-20)
Nan Wang, Jingyue Yang, Jianguo Lu, Qing Qiao, Tao Wu, Xilin Du, Guoqiang Bao, Xianli He
ABSTRACT

A neutral polysaccharide fraction (SMPA) prepared from the roots of Salvia miltiorrhiza by DEAE-cellulose and Sephadex G-100 chromatography was tested for its immune enhancing function in N-methyl-N'-nitro-nitrosoguanidine (MNNG)-induced gastric cancer rats by intragastric administration. SMPA (200mg/kg) treatment not only increased the body weight, but also improved the immune organ indices. Furthermore, studies of various immunological activities in gastric cancer rats revealed that SMPA significantly stimulated splenocyte proliferation, promoted anti-inflammatory cytokines (IL-2, IL-4 and IL-10) production, inhibited pro-inflammatory cytokine (IL-6 and TNF-α) secretion, augmented the killing activity of natural killer (NK) cells and cytotoxic T lymphocytes (CTL), and increased phagocytotic function of macrophages in gastric cancer rats. In addition, SMPA administration evidently elevated total intracellular granzyme-B and IFN-γ levels produced by splenocytes in gastric cancer rats. Taken together, these results suggested that SMPA could act as an effective immunomodulator and might be explored as a potential supplemental source for gastric cancer therapy.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
D-(−)-Arabinose, ≥98%
Sigma-Aldrich
L-(−)-Fucose, ≥99%
Sigma-Aldrich
D-(+)-Mannose, powder, BioReagent, suitable for cell culture
Sigma-Aldrich
D-(−)-Ribose, suitable for cell culture, BioReagent
Sigma-Aldrich
D-(−)-Ribose, 98%
Sigma-Aldrich
D-(−)-Ribose, ≥98%
Millipore
D-(−)-Arabinose, suitable for microbiology, ≥99.0%
Millipore
D-(+)-Galactose, suitable for microbiology, ≥99.0%
Sigma-Aldrich
D-(+)-Galactose, meets analytical specification of Ph. Eur., BP
Sigma-Aldrich
D-Glucuronic acid, ≥98% (GC)
Sigma-Aldrich
D-(+)-Mannose, BioUltra, ≥99.5% (sum of enantiomers, HPLC)
Millipore
D-(+)-Mannose, suitable for microbiology, ≥99%
Millipore
D-(+)-Mannose, ≥99.0% (sum of enantiomers, HPLC), suitable for microbiology
Sigma-Aldrich
D-(−)-Ribose, ≥99%
Sigma-Aldrich
D-(+)-Galactose, ≥98%
Supelco
Galactose, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
D-(+)-Mannose, wood, ≥99%
Galactose, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
D-(+)-Mannose, synthetic, ≥99%
Sigma-Aldrich
Mouse IgM ELISA Kit
Xylose, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
D-(+)-Galactose, powder, anhydrous, BioReagent, suitable for cell culture, suitable for insect cell culture
Sigma-Aldrich
D-(+)-Galactose, BioXtra, pH 5.0-7.0 (20 °C, 1 M in H2O), ≥99%
Sigma-Aldrich
D-(+)-Galactose, ≥99%
SAFC
Galactose, plant-derived
Sigma-Aldrich
Dimethyl sulfoxide, suitable for HPLC, ≥99.7%
Sigma-Aldrich
Trifluoroacetic acid, suitable for HPLC, ≥99.0%
Sigma-Aldrich
Dimethyl sulfoxide, Hybri-Max, sterile-filtered, BioReagent, suitable for hybridoma, ≥99.7%
Sigma-Aldrich
Dimethyl sulfoxide, meets EP testing specifications, meets USP testing specifications
Sigma-Aldrich
Dimethyl sulfoxide, PCR Reagent