We’re dedicated to supporting all your explorations. Learn about common C–H functionalization reactions so you can intuitively predict where and how to apply them and further explore the field with our new guide. Get your copy below.
C–H functionalization has been called the holy grail of synthetic organic chemistry. The reliable and predictable conversion of a C–H into a C–C, C–N, C–O or C–X bond in a selective and controlled fashion represents a host of benefits in terms of step economy and waste reduction, driving the current energetic pace of research in this area.
C–H functionalization not only expands the number of sites that can be targeted in a given molecule, multiplying the opportunities for elaborating it into a more complex product, but it also allows for completely different kinds of chemical bonds to be targeted, often with high chemoselectivity.
The life science business of Merk KGaA, Darmstadt, Germany has long partnered with the scientists in the field to support their explorations by sharing knowledge, providing educational resources, and being a reliable supplier of cutting-edge materials. This guide was developed in collaboration with chemists from the Center for Selective C-H Functionalization, a National Science Foundation Center for Chemical Innovation
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