COMT
catechol-O-methyltransferase
Sinônimos:
Espécies:
Human COMT (1312), Mouse Comt (12846), Rat Comt (24267), cow COMT (618278), domestic guinea pig Comt (100730509), domestic cat COMT (101097022), naked mole-rat Comt (101717730), chicken COMT (416783), Horse COMT (100146509), fruit fly comt (47091)
ID UniProtKB:
ID do gene:
- Human(1312) Summary: Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
- Mouse(12846) catechol-O-methyltransferase
- Rat(24267) catechol-O-methyltransferase
- cow(618278) catechol-O-methyltransferase
- domestic guinea pig(100730509) catechol-O-methyltransferase
- domestic cat(101097022) catechol-O-methyltransferase
- naked mole-rat(101717730) catechol-O-methyltransferase
- chicken(416783) catechol-O-methyltransferase
- Horse(100146509) catechol-O-methyltransferase
- fruit fly(47091) comatose
- dog(445450) catechol-O-methyltransferase
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Antibodies
Número do produto
Descrição
Reatividade de espécies
Aplicação
Anti-Catechol O-methyltransferase/COMT Antibody, from rabbit, purified by affinity chromatography,
Reatividade de espécies
bovine, horse, human, porcine, rhesus macaque
Aplicação
immunohistochemistry
western blot
western blot
Anti-COMT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reatividade de espécies
human, rat
Aplicação
western blot
Anti-COMT antibody produced in rabbit, affinity isolated antibody,
Reatividade de espécies
human
Aplicação
ELISA
western blot
western blot
Anti-COMT Antibody, clone 9Y2A3, Rabbit Monoclonal, ,
Reatividade de espécies
human, rat
Aplicação
western blot
Anti-COMT antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Reatividade de espécies
human, mouse, rat
Aplicação
immunoprecipitation (IP)
western blot
western blot
Small Molecule - Inhibitor
esiRNA
Número do produto
Descrição
Espécies