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Merck

PRNP

prion protein

Sinônimos:
ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30
Espécies:
Human PRNP (5621), Mouse Prnp (19122), Rat Prnp (24686), domestic cat PRNP (493886), chicken PRNP (396452), Horse PRNP (100065904), naked mole-rat Prnp (101710391), cow PRNP (281427), domestic guinea pig Prnp (100714701), sheep PRNP (493887) ...Mais
ID UniProtKB:
P04156, O60489, P78446, Q15216, Q15221, Q27H91, Q5QPB4, Q8TBG0
ID do gene:
  • Human(5621) Summary: The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
  • Mouse(19122) prion protein
  • Rat(24686) prion protein
  • domestic cat(493886) prion protein
  • chicken(396452) prion protein
  • Horse(100065904) prion protein
  • naked mole-rat(101710391) prion protein
  • cow(281427) prion protein
  • domestic guinea pig(100714701) prion protein
  • sheep(493887) prion protein
  • Domestic Rabbit(100345744) prion protein
  • dog(485783) prion protein

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Small Molecule - Antagonist

Número do produto
Descrição
Espécies
P13207
Phenazine, 98%,
Espécies
human

Antibodies

Número do produto
Descrição
Reatividade de espécies
Aplicação
MAB1562
Anticorpo antiproteína príon, a.a. 109-112, clone 3F4, clone 3F4, Chemicon®, from mouse,
Reatividade de espécies
hamster, human
Aplicação
ELISA
immunohistochemistry
immunoprecipitation (IP)
western blot
MABN2285M
Anti-Prion Protein Antibody, clone POM1, clone POM1, from mouse,
Reatividade de espécies
human, mouse
Aplicação
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
MABN2298M
Anti-Prion Protein Antibody, clone POM2, clone POM2, from mouse,
Reatividade de espécies
human, mouse
Aplicação
ELISA
immunocytochemistry
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
MAB5424
Anti-Prion Protein Antibody, Chemicon®, from mouse,
Reatividade de espécies
bovine, elk, mouse, mule deer, sheep
Aplicação
ELISA
immunohistochemistry
western blot
MABN768
Anti-PrP, clone DRM2-118 Antibody, clone DRM2-118, from mouse,
Reatividade de espécies
bovine, hamster, human, mouse, porcine, rat, sheep
Aplicação
ELISA
immunohistochemistry
western blot

Proteins

Número do produto
Descrição
Espécies
AG210
Prion Protein, recombinant, ,
Espécies
cow
P4238
Prion Protein Fragment 106-126 Scrambled Human, ≥85% (HPLC), solid,
Espécies
human
P3615
Prion Protein Fragment 106-126 Human, ≥90% (HPLC), solid,
Espécies
human

esiRNA

Número do produto
Descrição
Espécies
EHU046551
MISSION® esiRNA, targeting human PRNP,
Espécies
human