Hiroaki Akamatsu et al.
Japanese journal of clinical oncology, 43(6), 664-668 (2013-04-16)
Interstitial lung disease associated with gefitinib is a critical adverse reaction. When geftinib was administered to EGFR-unknown patients, the interstitial lung disease incidence rate was approximately 3-4% in Japan, and usually occurs during the first 4 weeks of treatment. However...
Shanshan Cui et al.
BMC structural biology, 13, 4-4 (2013-03-23)
To explore novel platinum-based anticancer agents that are distinct from the structure and interaction mode of the traditional cisplatin by forming the bifunctional intrastrand 1,2 GpG adduct, the monofunctional platinum+DNA adducts with extensive non-covalent interactions had been studied. It was...
Tao Xiong et al.
Journal of biomedical nanotechnology, 9(2), 274-280 (2013-05-01)
Noninvasive molecular fluorescence imaging in vivo which combines Optical imaging with genetic marker technology can real time monitor the development of tumor, through the use of human adenoid cystic carcinoma cell (ACC-M) and lung carcinoma cells SPC-A1 were thansfected by...
Wei Sun et al.
Materials science & engineering. C, Materials for biological applications, 33(4), 1907-1913 (2013-03-19)
In this paper a platinum (Pt) nanoparticle decorated graphene (GR) nanosheet was synthesized and used for the investigation on direct electrochemistry of myoglobin (Mb). By integrating GR-Pt nanocomposite with Mb on the surface of carbon ionic liquid electrode (CILE), a...
Yuan Xiong et al.
Organic letters, 15(8), 1962-1965 (2013-04-12)
Metal-mediated rearrangements of 3-alkynyl flavone ethers are reported. The overall process involves 5-endo enyne cyclization to a platinum-containing spiro-oxocarbenium intermediate which may be trapped with methanol to produce spirodihydrofurans or further rearranged to afford either allenyl chromanediones or benzofuranones.