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440191

Sigma-Aldrich

Hexamethyldisilazane

reagent grade, ≥99%

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Sinônimo(s):
Bis(trimethylsilyl)amine, HMDS
Fórmula linear:
(CH3)3SiNHSi(CH3)3
Número CAS:
Peso molecular:
161.39
Beilstein:
635752
Número CE:
Número MDL:
ID de substância PubChem:
NACRES:
NA.23

grau

reagent grade

Nível de qualidade

Ensaio

≥99%

forma

liquid

índice de refração

n20/D 1.407 (lit.)

pb

125 °C (lit.)

SMILES string

C[Si](C)(C)N[Si](C)(C)C

InChI

1S/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3

InChI key

FFUAGWLWBBFQJT-UHFFFAOYSA-N

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Este Item
379212526191.12186
Hexamethyldisilazane reagent grade, ≥99%

Sigma-Aldrich

440191

Hexamethyldisilazane

Hexamethyldisilazane ReagentPlus®, 99.9%

Sigma-Aldrich

379212

Hexamethyldisilazane

Hexamethyldisilazane for GC derivatization, LiChropur™, ≥99.0% (GC)

Supelco

52619

Hexamethyldisilazane

1,1,1,3,3,3-Hexamethyldisilazane for gas chromatography

Supelco

1.12186

1,1,1,3,3,3-Hexamethyldisilazane

assay

≥99%

assay

99.9%

assay

≥99.0% (GC)

assay

≥98.5% (GC)

form

liquid

form

liquid

form

liquid

form

liquid

refractive index

n20/D 1.407 (lit.)

refractive index

n20/D 1.407 (lit.)

refractive index

n20/D 1.407 (lit.), n20/D 1.408

refractive index

-

bp

125 °C (lit.)

bp

125 °C (lit.)

bp

125 °C (lit.)

bp

126 °C/1013 mbar

Descrição geral

Hexamethyldisilane (HMDS) is a stable and effectivereagent for trimethylsilylation of hydrogen-labile substrates such as alcohols,amines, and carboxylic acids. It is commonly used for the protection of sensitivefunctional groups during chemical synthesis. Owing to its low cost, high vapor pressure, and safety, itis widely used as a precursor in chemical vapor deposition(CVD) reactions.

Aplicação

Hexamethyldisilane (HMDS) can be used:
  • As a silylating agent in the trimethylsilylation of alcohols under nearly neutral reaction conditions.
  • To control the molecular weights of polypeptides during ring-opening polymerization of α-amino acid N-carboxyanhydrides.
  • To fabricate silicon carbonitride thin films by plasma-enhanced CVD.
  • For specimen preparation for scanning electron microscopy and the preparation of trimethylsilyl ethers from hydroxy compounds.

Características e benefícios

  • High chemicalstability and low molecular weight
  • Nontoxic andcost-effective reagent
  • Ammonia is theonly byproduct generated during silylation
  • Silylationreaction using HDMS is nearly neutral and does not need any precaution

Pictogramas

FlameSkull and crossbones

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Flam. Liq. 2

Código de classe de armazenamento

3 - Flammable liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

52.5 °F - closed cup

Ponto de fulgor (°C)

11.4 °C - closed cup

Equipamento de proteção individual

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


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Chlorotrimethylsilane ≥98.0% (GC)

Sigma-Aldrich

92361

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Lithium bis(trimethylsilyl)amide 97%

Sigma-Aldrich

324620

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Chlorotrimethylsilane purified by redistillation, ≥99%

Sigma-Aldrich

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Chlorotrimethylsilane

Hexamethyldisilathiane synthesis grade

Sigma-Aldrich

283134

Hexamethyldisilathiane

Sodium bis(trimethylsilyl)amide 95%

Sigma-Aldrich

235083

Sodium bis(trimethylsilyl)amide

Rapid and highly efficient trimethylsilylation of alcohols and phenols
with hexamethyldisilazane (HMDS) catalysed by in situ generated I2
using OxoneR /KI or cerium ammonium nitrate (CAN)/KI systems
under mild conditions
Eskandar K, et al.
Journal of Chemical Sciences (Bangalore), 123(5), 703-708 (2011)
F Braet et al.
Journal of microscopy, 186(Pt 1), 84-87 (1997-04-01)
Critical point drying (CPD) is a common method of drying biological specimens for scanning electron microscopy (SEM). Drying by evaporation of hexamethyldisilazane (HMDS) has been described as a good alternative. This method, however, is infrequently used. Therefore, we reassessed HMDS
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