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700312

Sigma-Aldrich

Iron oxide(II,III), magnetic nanoparticles solution

10 nm avg. part. size, 5 mg/mL in toluene

Sinônimo(s):
Magnetite, Superparamagnetic iron oxide nanoparticles, Magnetic iron oxide nanocrystals
Empirical Formula (Hill Notation):
Fe3O4
Número CAS:
Peso molecular:
231.53
Número MDL:
ID de substância PubChem:
NACRES:
NA.23

Nível de qualidade

100

forma

nanoparticles
solution

concentração

5 mg/mL in toluene

magnetização

>45 emu/g (at ambient temperature under 4500 Oe)

Tamanho médio da partícula

10 nm

tamanho de partícula

9-11 nm (TEM; conforms)

densidade

0.865 g/mL at 25 °C

SMILES string

O=[Fe].O=[Fe]O[Fe]=O

InChI

1S/3Fe.4O

InChI key

SZVJSHCCFOBDDC-UHFFFAOYSA-N

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Descrição geral

Iron oxide(II,III), magnetic nanoparticles solution (Fe3O4) is an organic solvent dispersed nanoparticle solution, which can be synthesized by the thermal decomposition of iron acetylacetonate in 2-pyrrolidone. It is majorly used in biomedical applications due to its magnetic properties, particle size, and surface properties.
It contains <1.0% oleic acid stabilizing ligands.
Concentration 5mg/ml includes total weight nanocrystals plus ligands.

Aplicação

Fe3O4 can be used in the targeting and imaging of tumor cells for cancer therapy-based applications. It may also be used in the separation of tumor cells from fresh whole blood. It can also be used as an effective material in drug delivery systems and magnetic resonance imaging (MRI).

Embalagem

5 mL in glass bottle

Palavra indicadora

Danger

Classificações de perigo

Aquatic Chronic 3 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 - STOT SE 3

Órgãos-alvo

Central nervous system

Código de classe de armazenamento

3 - Flammable liquids

WGK

WGK 2

Ponto de fulgor (ºF)

45.0 °F

Ponto de fulgor (ºC)

7.2 °C

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certificado de análise

Certificado de origem

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What method is used to determine the size of the particles in Product 700312, Iron oxide?

    TEM used to check particle size. Light Scattering or similar methods are not utilized.

  6. How is the magnetization of Product 700312, Iron oxide, determined?

    Per the supplier, the magnetization is determined by using a Magnetic Susceptibility Balance.

  7. What is the purpose of the oleic acid in Product 700312, Iron oxide? Can it be removed?

    Per the manufacturer, the oleic acid allows the iron oxide nanoparticles to be soluble in the solvent (i.e. toluene).

  8. What is the coating thickness of oleic acid on product number 700312, 700320, and 700304, Iron oxide(II,III), magnetic nanoparticles solution?

    The suppliers of the magnetic iron oxide nanoparticles in toluene have indicated that the particles are essentially coated with a monolayer of oleic acid. Since the oleic acid is a long chain hydrocarbon there can exist some folding and irregular structure on the surface.  The suppliers estimate that one should add 1-2 nm to the particle size due to the presence of the oleic acid coating. From this, 1.5 nm is the closest approximation of coating thickness as provided by our suppliers.

  9. How should a sample of the Iron oxide(II,III), magnetic nanoparticles solution in toluene be prepared for analysis by transmission electron microscopy (TEM)?

    The particle size is determined by TEM.If the solution as provided is not diluted, a superlattice of multilayer nanocrystals will form on the grid, appearing to be an aggregate. The solution can be diluted with the same solvent that it was shipped in (toluene). A solution diluted to 0.1-0.5 mg/mL should be concentrated enough to get a nice picture. One drop per grid should be sufficient. (Since the solution is provided at a concentration of 5 mg/mL, this would be a 10- to 50-fold dilution.)After applying the sample to the grid, a drying time of a minimum of 10-15 minutes is recommended.After performing several successful dilutions and getting good results, the analyst will get a feel for the correct dilution just by judging the color and darkness of the diluted sample. If you see lone isolated dots in the TEM, then your sample is too dilute. If you cannot distinguish separate particles, it is too concentrated. Good record keeping will help to zero in on the best dilution factor for the type of picture that you want.

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Nonpolymeric coatings of iron oxide colloids for biological use as magnetic resonance imaging contrast agents
Portet D, et al.
Journal of Colloid and Interface Science, 238(1), 37-42 (2001)
Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy
Peng X, et al.
International journal of nanomedicine, 3(3), 311-311 (2008)
Antibody conjugated magnetic iron oxide nanoparticles for cancer cell separation in fresh whole blood
Xu H, et al.
Biomaterials, 32(36), 9758-9765 (2011)
Superparamagnetic nanoparticles for biomedical applications: possibilities and limitations of a new drug delivery system
Neuberger T, et al.
Journal of magnetism and magnetic materials, 293(1), 483-496 (2005)
Synthesis of Fe3O4 nanoparticles with various sizes and magnetic properties by controlled hydrolysis
Iida H, et al.
Journal of Colloid and Interface Science, 314(1), 274-280 (2007)

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Synthesis and Application of Shape-Controlled Fe3O4 Nanostructure

Professor Yadong Yin (University of California Riverside, USA) examines both direct (thermal decomposition, solvothermal, hydrothermal) and indirect (templated) synthesis methods of magnetite nanocrystals and reviews in detail the landscape of these various synthetic methods for magnetite nanocrystal and their applications in magnetic assembly, magnetic hyperthermia, and Li-Ion batteries.

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