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711489

Sigma-Aldrich

1-Hydroxybenzotriazole hydrate

wetted with not less than 20 wt. % water, 97% dry basis

Sinônimo(s):

HOBt Hydrate

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About This Item

Fórmula empírica (Notação de Hill):
C6H5N3O · xH2O
Número CAS:
123333-53-9
Peso molecular:
135.12 (anhydrous basis)
Beilstein:
4515
Número CE:
219-989-7
Código UNSPSC:
12352000
ID de substância PubChem:
329763060
NACRES:
NA.22

Ensaio

97% dry basis

forma

powder

qualidade

wetted with not less than 20 wt. % water

composição

Water content, ~20%

adequação da reação

reaction type: Addition Reactions

pf

155-158 °C (lit.)

solubilidade

DMF: 0.1 g/mL, clear

cadeia de caracteres SMILES

[H]O[H].On1nnc2ccccc12

InChI

1S/C6H5N3O.H2O/c10-9-6-4-2-1-3-5(6)7-8-9;/h1-4,10H;1H2

chave InChI

PJUPKRYGDFTMTM-UHFFFAOYSA-N

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Descrição geral

1-Hydroxybenzotriazolehydrate (HOBt hydrate) is a hydrated form of HOBt. HOBt is a nucleophilic additive commonly used in synthetic chemistry. It is widely employed as acatalyst or stoichiometric additive to accelerate nucleophilic acyl substitution reactions, specifically amidations. Additionally, it is also used in the synthesis of peptides and nucleotides.

Aplicação

1-Hydroxybenzotriazole hydrate is used as an additive:
  • In the oligonucleotide couplings.
  • In the preparation of poly(ethylene glycol)methyl ether-grafted CTS (mPEG-g-CTS).
1-Hydroxybenzotriazole hydrate can also be used:
  • In the solid phase peptide synthesis on TCNEO(tetracyanoethylene oxide)-modified graphite.

Pictogramas

FlameExclamation mark
GHS02,GHS07

Palavra indicadora

Danger

Frases de perigo

H207,H319,H412

Classificações de perigo

Aquatic Chronic 3 - Desen. Expl. 2 - Eye Irrit. 2

Código de classe de armazenamento

4.1A - Other explosive hazardous materials

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

314.6 °F

Ponto de fulgor (°C)

157 °C

Equipamento de proteção individual

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Certificados de análise (COA)

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