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Merck

941174

NanoFabTx™ photoactivatable lipid mix

AzoPC, for small molecule delivery

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description

Technique(s): microfluidics, extrusion, flash nanoprecipitation

form

(powder, chunks, sold)

composition

AzoPC , Contains: DSPC, Cholesterol, AzoPC

color

white to off-white

suitability

suitable for ( small molecule delivery)

functional group

(Photoswitchable AzoPC)

storage temp.

−20°C

Quality Level

100

General description

About the material:

NanoFabTx™ AzoPC Lipid Mix is a curated lipid mixture designed for the synthesis of photoactivatable liposomes. This ready-to-use lipid mix contains carefully selected lipids and comes with detailed step-by-step instructions for the synthesis process.

The photoactivatable lipid AzoPC exhibits cytotoxicity upon exposure to UV-A light in human cancer cell lines, leading to the release of its payload upon photoactivation. Notably, the photoactivatable liposomes themselves are non-cytotoxic in the absence of light.

For further details and a comprehensive step-by-step protocol, please refer to the "More Documents" section on this page.

Application

The NanoFabTx™ photoactivatable AzoPC lipid mix can be used to:

  • Enable the synthesis of photoactivatable liposomes for targeted drug delivery
  • Allow controlled release of payload upon photoactivation
  • Research and development in the field of targeted cancer therapy and drug delivery technologies

Features and Benefits

  • A ready-to-use lipid blend for the synthesis of photoactivatable liposomes.
  • Step-by-step protocols (microfluidics) developed and tested by our formulation scientists
  • Flexible synthesis tool to create uniform and reproducible liposomes
Comprehensive protocols for liposome synthesis are included:
  • A microfluidics protocol using commercial platforms or syringe pumps
The microfluidics protocol included with this product uses the NanoFabTx™ device kit (911593). These kits come with the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

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