P56100

Sigma-Aldrich

Pyrazinecarboxylic acid

99%

Sinônimo(s):
Pyrazinoic acid
Empirical Formula (Hill Notation):
C5H4N2O2
Número CAS:
Peso molecular:
124.10
Beilstein/REAXYS Number:
112305
Número EC:
Número MDL:
ID de substância PubChem:
NACRES:
NA.22

Nível de qualidade

200

teor

99%

pf

222-225 °C (dec.) (lit.)

SMILES string

OC(=O)c1cnccn1

InChI

1S/C5H4N2O2/c8-5(9)4-3-6-1-2-7-4/h1-3H,(H,8,9)

InChI key

NIPZZXUFJPQHNH-UHFFFAOYSA-N

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Categorias relacionadas

storage_class_code

13 - Non Combustible Solids

WGK Alemanha

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificado de análise

Certificado de origem

Mohamed Abdel-Aziz et al.
European journal of medicinal chemistry, 45(8), 3384-3388 (2010-05-22)
A series of pyrazine-2-carboxylic acid hydrazide derivatives were synthesized and screened for their activity against Mycobacterium tuberculosis. The results show that pyrazine-2-carboxylic acid hydrazide-hydrazone derivatives 3a-l were less active than pyrazinamide. In contrast, the N(4)-ethyl-N(1)-pyrazinoyl-thiosemicarbazide 4 showed the highest activity...
Wolfgang Holzer et al.
Magnetic resonance in chemistry : MRC, 47(7), 617-624 (2009-04-30)
NMR spectroscopic studies are undertaken with derivatives of 2-pyrazinecarboxylic acid. Complete and unambiguous assignment of chemical shifts ((1)H, (13)C, (15)N) and coupling constants ((1)H,(1)H; (13)C,(1)H; (15)N,(1)H) is achieved by combined application of various 1D and 2D NMR spectroscopic techniques. Unequivocal...
Mirko Zimic et al.
Tuberculosis (Edinburgh, Scotland), 92(1), 84-91 (2011-10-19)
Pyrazinamide is one of the most important drugs in the treatment of latent Mycobacterium tuberculosis infection. The emergence of strains resistant to pyrazinamide represents an important public health problem, as both first- and second-line treatment regimens include pyrazinamide. The accepted...
Stefania Tanase et al.
Dalton transactions (Cambridge, England : 2003), (15)(15), 2026-2033 (2008-04-03)
The reactivity towards H(2)O(2) of the complexes [Fe(pca)(2)(py)(2)].py (1) and Na(2){[Fe(pca(3))](2)O}.2H(2)O.CH(3)CN (2) (where pca(-) is pyrazine-2-carboxylate) and their catalytic activity in the oxidation of hydrocarbons is reported. Addition of H(2)O(2) to 1 results in the formation of a dinuclear Fe(III)-(mu-O)-Fe(III)...
Ping Lu et al.
Antimicrobial agents and chemotherapy, 55(11), 5354-5357 (2011-08-31)
Pyrazinoic acid, the active form of the first-line antituberculosis drug pyrazinamide, decreased the proton motive force and respiratory ATP synthesis rates in subcellular mycobacterial membrane assays. Pyrazinoic acid also significantly lowered cellular ATP levels in Mycobacterium bovis BCG. These results...

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