850725P

18:1 (Δ9-Cis) PE (DOPE)

Avanti Research^™ - A Croda Brand

• Sinônimo(s): 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; DOPE; PE(18:1(9Z)/18:1(9Z)); 110635, DOPE
• Fórmula empírica (Notação de Hill): C₄₁H₇₈NO₈P
• Número CAS: 4004-05-1
• Peso molecular: 744.03
• MDL number: MFCD02259123
• UNSPSC Code: 51191904
• NACRES: NA.25

Propriedades

• SMILES string: [H][C@@](COP([O-])(OCC[NH3+])=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O
• InChI: 1S/C41H78NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,39H,3-16,21-38,42H2,1-2H3,(H,45,46)/b19-17-,20-18-/t39-/m1/s1
• InChI key: MWRBNPKJOOWZPW-NYVOMTAGSA-N
• description: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine
• assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 1 g (850725P-1g), pkg of 2 × 100 mg (850725P-200mg), pkg of 5 × 100 mg (850725P-500mg), pkg of 1 × 25 mg (850725P-25mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• application(s): advanced drug delivery
• lipid type: cardiolipins; phospholipids
• shipped in: dry ice
• storage temp.: −20°C

Descrição

Application

18:1 (Δ9-Cis) PE (DOPE) has been used in the preparation of liposome for human uncoupling protein 1 (UCP1) reconstitution[1] and for Caenorhabditis elegans autophagy related cysteine protease protein conjugation studies.[2] It has also been used for the generation of giant unilamellar vesicles (GUVs) for septin induced deformation studies.[3]

Biochem/physiol Actions

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (18:1 (Δ9-Cis) PE (DOPE)) forms a stable lipid layer and rapidly fuses with endosomal lipid bilayer.[4] DOPE in combination with 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) has high in vitro transfection efficiency.[5]

General description

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (18:1 (Δ9-Cis) PE (DOPE)) is a neutral phospholipid and displays sensitivity towards pH change. At acidic it is an inverted hexagonal micelle and transforms to spherical micelle at alkaline pH.[6]

Packaging

20 mL Clear Glass Screw Cap Vial (850725P-1g)

5 mL Clear Glass Sealed Ampule (850725P-200mg)

5 mL Clear Glass Sealed Ampule (850725P-25mg)

5 mL Clear Glass Sealed Ampule (850725P-500mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informações de segurança

• Classe de armazenamento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable