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05-23-0101

Sigma-Aldrich

Angiotensin II, Human

Plays an important role in the regulation of blood pressure.

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Sinônimo(s):
Angiotensin II, Human, DRVYIHPF
Empirical Formula (Hill Notation):
C50H71N13O12
Número CAS:
Peso molecular:
1046.18

Nível de qualidade

esterilidade

non-sterile

Ensaio

≥98% (HPLC)

forma

solid

manufacturer/tradename

Calbiochem®

condição de armazenamento

OK to freeze
desiccated (hygroscopic)

cor

white to off-white

solubilidade

5% acetic acid: 1 mg/mL
water: 1 mg/mL

enviado em

ambient

temperatura de armazenamento

−20°C

InChI

1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41?/m0/s1

InChI key

CZGUSIXMZVURDU-GYGDIBSWSA-N

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Este Item
A952505-23-0310A8846
Sigma-Aldrich

Sigma-Aldrich

05-23-0101

Angiotensin II, Human

Angiotensin II human ≥93% (HPLC), powder

Sigma-Aldrich

A9525

Angiotensin II human

assay

≥98% (HPLC)

assay

≥93% (HPLC)

assay

≥96% (HPLC)

assay

-

form

solid

form

powder

form

lyophilized solid

form

-

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

storage condition

OK to freeze, desiccated

storage condition

-

solubility

5% acetic acid: 1 mg/mL, water: 1 mg/mL

solubility

water: 25 mg/mL, clear, colorless

solubility

5% acetic acid: 1 mg/mL

solubility

-

shipped in

ambient

shipped in

-

shipped in

ambient

shipped in

-

Descrição geral

Plays an important role in the regulation of blood pressure. Stimulates the release of aldosterone from the adrenal gland. Inhibits adenylate cyclase activity in spontaneously hypertensive rats. Has strong vasoconstrictive effects. Increases the entry of Ca2+ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase. Also elicits an increase in voltage-dependent delayed rectifier K+ current in neurons. Activates JAK2 in smooth muscle cells. Activates p125FAK and a cytosolic 115-120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. Also activates p60c-srcas well as ERK1/2, JNK, and p38 MAP Kinase in vascular smooth muscle cells.

Ações bioquímicas/fisiológicas

Cell permeable: no
Primary Target
adenylate cyclase activity
Product does not compete with ATP.
Reversible: no

Embalagem

Yes

Advertência

Toxicity: Standard Handling (A)

Sequência

H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.

Outras notas

Zhu, M., et al. 2000. J. Neurophysiol.84, 2494.
Natarajan, R., et al. 1999. Hypertension 33, 378.
Mazzolai, L., et al. 1998. Hypertension 31, 1324.
Earp, H.S., et al. 1995. J. Biol. Chem. 270, 28440.
Ishida, M., et al. 1995. Circ. Res. 77, 1053.
Vyas, S.J., and Jackson, E.K. 1995. J. Pharmacol. Exp. Ther. 273, 768.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de classe de armazenamento

11 - Combustible Solids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable


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