Merck
All Photos(3)

1.08386

SAFC

Tris(hydroxymethyl)aminomethane

(Trometamol), EMPROVE® ESSENTIAL, Ph. Eur., BP, ChP, JPC, USP

Synonym(s):
Tris base, Trometamol, 2-Amino-2-(hydroxymethyl)-1,3-propanediol, THAM, Tromethamine
Linear Formula:
NH2C(CH2OH)3
CAS Number:
Molecular Weight:
121.14
Beilstein:
741883
Número MDL:
Número do índice EC:
201-064-4

Nível de qualidade

500

Agency

BP
ChP
JPC
Ph. Eur.
USP

pressão de vapor

0.0267 hPa ( 20 °C)

linha de produto

EMPROVE® ESSENTIAL

forma

solid

pH

10.2-10.6 (20 °C, 6 g/L in H2O)

useful pH range

7-9

pKa (25 °C)

8.1

pb

219-220 °C/10 mmHg (lit.)
219-220 °C/13.3 hPa

pf

167-172 °C (lit.)

solubilidade

678 g/L

densidade

1.35 g/cm3 at 23 °C

application(s)

ophthalmics
pharmaceutical

temperatura de armazenamento

no temp limit

SMILES string

NC(CO)(CO)CO

InChI

1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2

InChI key

LENZDBCJOHFCAS-UHFFFAOYSA-N

Descrição geral

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Aplicação

Tris(hydroxymethyl)aminomethane (Trometamol) is a commonly used buffer component in biomolecule downstream chromatography steps as well as final liquid formulation.

Informações legais

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de classe de armazenamento

11 - Combustible Solids

WGK

WGK 1

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Certificate of Analysis

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Certificate of Quality

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What is the Emprove® Program?

The Emprove® Program is a system providing comprehensive and thorough documentation of our filters and single-use components, pharma raw materials, and starting materials.

Material Qualification Dossier

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Quality Management Dossier

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Operational Excellence Dossier

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Why are these documents unavailable?
Emprove® Dossiers contain information intended to support the registration process and risk assessment activities of pharmaceutical producers and contain confidential information. Please contact us if you would like access.

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