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Wortmannin, (PI3 Kinase inhibitor)

The Wortmannin, (PI3 Kinase inhibitor) controls the biological activity of PI3 Kinase. This small molecule/inhibitor is primarily used for Biochemicals applications.


Nível de qualidade


≥95% (HPLC)




activity assay: suitable (kinase)

nº de adesão NCBI

nº de adesão UniProt

enviado em

wet ice

Descrição geral

Wortmannin, a fungal metabolite, is a cell-permeable, irreversible inhibitor of phosphatidylinositol 3 kinase (PI3 Kinase) with an IC50 of 5nM. It blocks the catalytic activity of PI3-Kinase without affecting upstream signaling events such as insulin receptor tyrosine kinase activity. Wortmannin also inhibits the activities of myosin light chain kinase and PI4-Kinase at concentrations a hundred times higher than those required to inhibit PI3-Kinase.

Ações bioquímicas/fisiológicas

Inhibitor Type: Kinase
Protein Target: PI3Kγ
Target Sub-Family: PI3K/PI4K


Routinely evaluated by kinase assay.
Purity: ≥95% by HPLC.
Molecular Formula: C23H24O8
Molecular Weight: 428.4

forma física

1mg of lyophilized powder packaged under inert gas. White to off-white powder.

Armazenamento e estabilidade

Protect from light. Stable for 2 years as supplied at -20°C. Following reconstitution aliquot and store at -20°. The DMSO/ethanol stock solutions are stable for 1-3 months at -20°C.

Informações legais

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


Skull and crossbones

Palavra indicadora


Frases de perigo

Classificações de perigo

Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Acute Tox. 2 Dermal

Código de classe de armazenamento

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials



Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

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