227056

N,N-Dimethylformamide

anhydrous, 99.8%

• Synonym(s): DMF, NSC 5356
• Linear Formula: HCON(CH₃)₂
• CAS Number: 68-12-2
• Molecular Weight: 73.09
• Beilstein: 605365
• Número EC: 200-679-5
• Número MDL: MFCD00003284
• ID de substância PubChem: 57647999
• NACRES: NA.21

Properties

• Nível de qualidade: 300
• grau: anhydrous
• densidade de vapor: 2.5 (vs air)
• pressão de vapor: 2.7 mmHg ( 20 °C)
• teor: 99.8%
• forma: liquid
• temperatura de autoignição: 833 °F
• Lim. expl.: 15.2 %
• Impurezas: <0.005% water
• resíduo de evaporação: <0.0005%
• índice de refração: n20/D 1.430 (lit.)
• pH: 7 (20 °C, 200 g/L)
• pb: 153 °C (lit.)
• pf: −61 °C (lit.)
• densidade: 0.944 g/mL (lit.)
• SMILES string: [H]C(=O)N(C)C
• InChI: 1S/C3H7NO/c1-4(2)3-5/h3H,1-2H3
• InChI key: ZMXDDKWLCZADIW-UHFFFAOYSA-N

Description

Descrição geral

N,N-Dimethylformamide (DMF) is the commonly employed solvent for chemical reactions. DMF is a useful solvent employed for the isolation of chlorophyll from plant tissues. It is widely employed reagent in organic synthesis. It plays multiple roles in various reactions such as solvent, dehydrating agent, reducing agent as well as catalyst. It is a multipurpose building block for the synthesis of compounds containing O, -CO, -NMe₂, -CONMe₂, -Me, -CHO as functional groups.

N,N-Dimethylformamide is a polar solvent commonly used in organic synthesis. It also acts as a multipurpose precursor for formylation, amination, aminocarbonylation, amidation and cyanation reactions.

Aplicação

N,N-Dimethylformamide (anhydrous) has been used as solvent for the synthesis of cytotoxic luteinizing hormone-releasing hormone (LH-RH) conjugate AN-152 (a chemotherapeutic drug) and fluorophore C625 [4-(N,N-diphenylamino)-4′-(6-O-hemiglutarate)hexylsulfinyl stilbene]. It may be employed as solvent medium for the various organic reduction reactions.

DMF has been used as a solvent in the following processes:

• Multi-step synthesis of L-azidohomoalanine (L-Aha) during the substitution of the mesylate by sodium azide.
• Synthesis of phosphine-FLAG^®, a detection reagent for metabolic labeling of glycans.
• Synthesis of per-O-acetylated 6-azidofucose, a per-O-acetylated azido sugar.

Solvent for many hydrophobic organic compounds.

Embalagem

18, 200 L in Pure-Pac™ 1

1, 6×1, 2, 4×2 L in Sure/Seal™

100, 12×100 mL in Sure/Seal™

View returnable container options.

Informações legais

FLAG is a registered trademark of Sigma-Aldrich Co. LLC

Safety Information

• Pictogramas: GHS02,GHS07,GHS08
• Palavra indicadora: Danger
• Frases de perigo: H226 - H312 + H332 - H319 - H360D
• Declarações de precaução: P210 - P280 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
• Classificações de perigo: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 1B
• Código de classe de armazenamento: 3 - Flammable liquids
• WGK: WGK 2
• Ponto de fulgor (ºF): 135.5 °F - closed cup
• Ponto de fulgor (ºC): 57.5 °C - closed cup
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter