271004

Sigma-Aldrich

Acetonitrile

anhydrous, 99.8%

Sinônimo(s):
Cyanomethane, Methyl cyanide, ACN, Ethyl nitrile
Fórmula linear:
CH3CN
Número CAS:
Peso molecular:
41.05
Beilstein/REAXYS Number:
741857
Número EC:
Número MDL:
eCl@ss:
39031501
ID de substância PubChem:
NACRES:
NA.21

Nível de qualidade

200

grau

anhydrous

densidade de vapor

1.41 (vs air)

pressão de vapor

72.8 mmHg ( 20 °C)

teor

99.8%

forma

liquid

temperatura de autoignição

973 °F

Lim. expl.

16 %

aplicação(ões)

solid phase extraction (SPE): suitable

Impurezas

<0.001% water
<0.005% water (100 mL pkg)

resíduo de evaporação

<0.0005%

cor

colorless

índice de refração

n20/D 1.344 (lit.)

pb

81-82 °C (lit.)

pf

−45 °C (lit.)

solubilidade

water: soluble (completely)

densidade

0.786 g/mL at 25 °C (lit.)

SMILES string

CC#N

InChI

1S/C2H3N/c1-2-3/h1H3

InChI key

WEVYAHXRMPXWCK-UHFFFAOYSA-N

Procurando produtos similares? Visit Guia de comparação de produtos

Categorias relacionadas

Descrição geral

Acetonitrile, an aliphatic nitrile, is widely used as an organic solvent and intermediate in organic syntheses. It is transparent to UV-visible light, which makes it highly applicable in spectrophotometric and fluorimetric techniques. MeCN is utilized as a mobile phase component in many chromatographic techniques, due to its low viscosity, high elution strength and miscibility in water. It also plays a major role as an extractant medium in liquid-liquid extraction, solid-phase extraction or microextraction.

Aplicação

Acetonitrile may be used as a solvent to prepare:
  • 1,2-Azidoalcohols and 1,2-azidoamines via cerium(III) chloride assisted ring opening of epoxides and aziridines by sodium azide.
  • Cyano-bearing indolinones by oxidative arylalkylation of olefins in the presence of palladium catalyst.

It may also be used as a reactant to synthesize:
  • Bis (diphenylphosphino) acetonitrile by reacting with n-butyllithium and then with chlorodiphenylphosphine.
  • β-Acetamido ketones via coupling reaction with ketones or ketoesters and aldehydes in the presence of cobalt(II) chloride.

Embalagem

1, 6×1, 2, 4×2 L in Sure/Seal™
100, 12×100 mL in Sure/Seal™
200 L in Pure-Pac™ 1
18 L in Pure-Pac™ 1
20, 50 L in Pure-Pac™ 2

Pictogramas

FlameExclamation mark

Palavra indicadora

Danger

hazcat

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

storage_class_code

3 - Flammable liquids

WGK Alemanha

WGK 2

Ponto de fulgor (ºF)

35.6 °F - closed cup

Ponto de fulgor (ºC)

2.0 °C - closed cup

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certificado de análise

Certificado de origem

Cobalt-catalysed three-component coupling involving ketones or ketoesters, aldehydes and acetonitrile: a novel one-pot synthesis of ?-acetamido ketones
Madhavaa Reddy M.
Journal of the Chemical Society. Chemical Communications, 6, 713-714 (1994)
Bis (diphenylphosphino) acetonitrile: Synthesis, ligand properties and application in catalytic carbon?carbon coupling
Braun L, et al.
Dalton Transactions, 14, 1409-1415 (2007)
Eagleson M.
Concise Encyclopedia Chemistry, 56-56 (1994)
Cerium (III) chloride promoted highly regioselective ring opening of epoxides and aziridines using NaN3 in acetonitrile: a facile synthesis of 1,2-azidoalcohols and 1,2-azidoamines.
Sabitha G, et al.
Organic Letters, 4(3), 343-345 (2002)
Palladium-Catalyzed Oxidative Arylalkylation of Activated Alkenes: Dual C-H Bond Cleavage of an Arene and Acetonitrile.
Wu T, et al.
Angewandte Chemie (International Edition in English), 50(52), 12578-12581 (2011)
Artigos
Amide bonds are ubiquitous in both nature and industrial applications. They are vital to the structure and function of biological macromolecules and polymers. The importance of this functionality has resulted in numerous approaches to its formation, ranging from stoichiometric activation of carboxylic acids to more recent advances in catalytic amide bond formation.
Leia mais

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica