33894

Clotrimazole

VETRANAL^®, analytical standard

• Sinônimo(s): 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole, 1-(o-Chlorotrityl)imidazole, 1-(o-Chloro-α,α-diphenylbenzyl)imidazole
• Empirical Formula (Hill Notation): C₂₂H₁₇ClN₂
• Número CAS: 23593-75-1
• Peso molecular: 344.84
• Número EC: 245-764-8
• Número MDL: MFCD00057220
• ID de substância PubChem: 329754531
• NACRES: NA.24

Propriedades

• grau: analytical standard
• linha de produto: VETRANAL^®
• prazo de validade: limited shelf life, expiry date on the label
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• espectro de atividade do antibiótico: fungi
• application(s): agriculture; environmental
• formato: neat
• Modo de ação: protein synthesis | interferes
• SMILES string: Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4
• InChI: 1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
• InChI key: VNFPBHJOKIVQEB-UHFFFAOYSA-N

Descrição

Descrição geral

Its mode of action involves the inhibition of ergosterol synthesis, which leads to structural and functional damage of the cell membrane.

Clotrimazole, a non-toxic, systemic, imidazole derivative with broad-spectrum antimycotic activity, is primarily used in the treatment of oropharyngeal candidiasis.

Aplicação

Clotrimazole may be used as a reference standard for the determination of the analyte in topical creams and ear drops by reversed-phase high-performance liquid chromatographic (RP-HPLC) method.

Clotrimazole may be used as an analytical reference standard for the determination of the analyte in:

• Milk samples using solid-phase extraction followed by high-performance liquid chromatography (SPE-HPLC).
• Environmental water samples using dispersive liquid-liquid microextraction followed by high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS).

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Informações legais

VETRANAL is a registered trademark of Sigma-Aldrich Chemie GmbH

Informações de segurança

• Pictogramas: GHS07,GHS09
• Palavra indicadora: Warning
• Frases de perigo: H302 - H315 - H319 - H410
• Declarações de precaução: P264 - P270 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
• Código de classe de armazenamento: 11 - Combustible Solids
• WGK: WGK 3
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves