Merck
Todas as fotos(1)

33894

Supelco

Clotrimazole

VETRANAL®, analytical standard

Sinônimo(s):
1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole, 1-(o-Chlorotrityl)imidazole, 1-(o-Chloro-α,α-diphenylbenzyl)imidazole
Empirical Formula (Hill Notation):
C22H17ClN2
Número CAS:
Peso molecular:
344.84
Número EC:
Número MDL:
ID de substância PubChem:
NACRES:
NA.24

grau

analytical standard

linha de produto

VETRANAL®

prazo de validade

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

espectro de atividade do antibiótico

fungi

application(s)

agriculture
environmental

formato

neat

Modo de ação

protein synthesis | interferes

SMILES string

Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4

InChI

1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H

InChI key

VNFPBHJOKIVQEB-UHFFFAOYSA-N

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Descrição geral

Its mode of action involves the inhibition of ergosterol synthesis, which leads to structural and functional damage of the cell membrane.
Clotrimazole, a non-toxic, systemic, imidazole derivative with broad-spectrum antimycotic activity, is primarily used in the treatment of oropharyngeal candidiasis.

Aplicação

Clotrimazole may be used as a reference standard for the determination of the analyte in topical creams and ear drops by reversed-phase high-performance liquid chromatographic (RP-HPLC) method.
Clotrimazole may be used as an analytical reference standard for the determination of the analyte in:
  • Milk samples using solid-phase extraction followed by high-performance liquid chromatography (SPE-HPLC).
  • Environmental water samples using dispersive liquid-liquid microextraction followed by high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS).

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Informações legais

VETRANAL is a registered trademark of Sigma-Aldrich Chemie GmbH

Pictogramas

Exclamation markEnvironment

Palavra indicadora

Warning

Classificações de perigo

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2

Código de classe de armazenamento

11 - Combustible Solids

WGK

WGK 3

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificado de análise

Insira o número de lote para pesquisar o Certificado de análise (COA).

Certificado de origem

Insira o número de lote para pesquisar o Certificado de origem (COO).

Mais documentos

Quotes and Ordering

SPE-HPLC method for determination of ketoconazole and clotrimazole residues in cow's milk.
Beigi KAF, et al.
Journal of the Brazilian Chemical Society, 22(9), 1679-1685 (2011)
Clotrimazole is effective for the regression of endometriotic implants in a Wistar rat experimental model of endometriosis.
Machado D, et al.
Molecular and Cellular Endocrinology, 476, 17-26 (2018)
Mode of action of clotrimazole.
Iwata K, et al.
Sabouraudia, 11(2), 158-166 (1973)
Application of dispersive liquid--liquid microextraction followed by HPLC-MS/MS for the trace determination of clotrimazole in environmental water samples.
Zgola?Grzeskowiak A and Grzeskowiak T
Journal of Separation Science, 36(15), 1514-1521 (2013)
Clotrimazole treatment for prevention of oral candidiasis in patients with acute leukemia undergoing chemotherapy: Results of a double-blind study.
Cuttner J, et al.
The American Journal of Medicine, 81(5), 771-774 (1986)

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