Merck
All Photos(1)

52619

Supelco

Hexamethyldisilazane

for GC derivatization, LiChropur, ≥99.0% (GC)

Synonym(s):
HMDS
Linear Formula:
(CH3)3SiNHSi(CH3)3
CAS Number:
Molecular Weight:
161.39
Beilstein:
635752
Número EC:
Número MDL:
ID de substância PubChem:

grau

for GC derivatization

Nível de qualidade

100

teor

≥99.0% (GC)

forma

liquid

qualidade

LiChropur

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

índice de refração

n20/D 1.407 (lit.)
n20/D 1.408

pb

125 °C (lit.)

SMILES string

C[Si](C)(C)N[Si](C)(C)C

InChI

1S/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3

InChI key

FFUAGWLWBBFQJT-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Descrição geral

Hexamethyldisilazane (HMDS) is a commercially available, silylating agent, which is used as an alternative for the preparation of silyl ethers from hydroxyl compounds.

Aplicação

Learn more in the Product Information
Hexamethyldisilazane is suitable for the derivatization of alcohols, U-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol, 4-hydroxycoumarins, hydroxyfatty acids, n-hydroxy-2-fluorenylacetamide, kerb cycle acid, malonaldehyde, monoglycerides, phenylpyruvic acid, shikimic acid, unsaturated fatty acid esters (or methyl esters), and related compounds.

It may be used as a derivatizing reagent for the analysis of bioamines and their acidic metabolites, phenol, hydroquinone and catechol in urine samples, mixtures of free fatty acids and metal soaps in paint samples using gas chromatography/mass spectrometry (GC/MS).
Suitable for the derivatization of alcohols, Υ-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol, 4-hydroxycoumarins, hydroxyfatty acids, n-hydroxy-2-fluorenylacetamide, kerb cycle acid, malonaldehyde, monoglycerides, phenylpyruvic acid, shikimic acid, unsaturated fatty acid esters (or methyl esters), and related compounds.

Características e benefícios

  • HMDS is inexpensive and has a relatively low boiling point (124-127 °C).        
  • It can be used without solvent but its silylating power can be increased by various (mostly acidic) catalysts.        
  • The only reaction byproduct, ammonia, can leave the reaction mixture as the reaction goes to completion.

Outras notas

Important silylating agent
Reagent for 2-hydroxypyrimidine, polytrimethylsilyloxy, trimethylsilyl and trimethylsilyl oximes.

Informações legais

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Pictogramas

FlameSkull and crossbones

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Flam. Liq. 2

Código de classe de armazenamento

3 - Flammable liquids

WGK

WGK 2

Ponto de fulgor (ºF)

52.5 °F - closed cup

Ponto de fulgor (ºC)

11.4 °C - closed cup

Equipamento de proteção individual

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service