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82280

Sigma-Aldrich

1,2-Propanediol

puriss. p.a., ACS reagent, ≥99.5% (GC)

Sinônimo(s):
1,2-PDO, Propylene glycol
Fórmula linear:
CH3CH(OH)CH2OH
Número CAS:
Peso molecular:
76.09
Beilstein:
1340498
Número EC:
Número MDL:
ID de substância PubChem:
NACRES:
NA.21

Nível de qualidade

200

grau

ACS reagent
puriss. p.a.

densidade de vapor

2.62 (vs air)

pressão de vapor

0.08 mmHg ( 20 °C)

teor

≥99.5% (GC)

forma

viscous liquid

temperatura de autoignição

779 °F

prazo de validade

3 yr

Lim. expl.

12.5 %

Impurezas

≤0.003% free acid (as CH3COOH)
≤0.1% water

resíduo de evaporação

≤0.005%

resíduo de ignição

<0.005% (as SO4)

índice de refração

n20/D 1.432 (lit.)
n20/D 1.433

pb

187 °C (lit.)

pf

−60 °C (lit.)

densidade

1.036 g/mL at 25 °C (lit.)

traços de ânion

chloride (Cl-): ≤1 mg/kg
sulfate (SO42-): ≤20 mg/kg

traços de cátion

Ca: ≤5 mg/kg
Cd: ≤1 mg/kg
Co: ≤1 mg/kg
Cr: ≤1 mg/kg
Cu: ≤1 mg/kg
Fe: ≤1 mg/kg
K: ≤20 mg/kg
Mg: ≤1 mg/kg
Mn: ≤1 mg/kg
Na: ≤20 mg/kg
Ni: ≤1 mg/kg
Pb: ≤1 mg/kg
Zn: ≤5 mg/kg

SMILES string

CC(O)CO

InChI

1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3

InChI key

DNIAPMSPPWPWGF-UHFFFAOYSA-N

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Descrição geral

1,2-Propanediol is a 1,2-alkanediol. It can be obtained from glycerol, via hydrogenolysis in the presence of Ru/C and Amberlyst ion-exchange resins.

Aplicação

1,2-Propanediol (propanediol) may be employed as a cryoprotective agent for the preservation (by cooling to sub-zero temperatures) of human embryos and oocytes (human and mouse).

Outras notas

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 82280.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Ponto de fulgor (ºF)

219.2 °F - closed cup

Ponto de fulgor (ºC)

104 °C - closed cup

Equipamento de proteção individual

Eyeshields, Gloves

Certificado de análise

Certificado de origem

D A Gook et al.
Human reproduction (Oxford, England), 8(7), 1101-1109 (1993-07-01)
Human and mouse oocytes were cryopreserved by a slow freeze, rapid thaw method, using propanediol (PROH) as the cryoprotectant. A simulated cryopreservation was also included in the study to detect the level of damage attributable to the PROH alone. Comparison...
Glycerol hydrogenolysis to 1, 2-propanediol catalyzed by a heat-resistant ion-exchange resin combined with Ru/C.
Miyazawa T, et al.
Applied Catalysis A: General, 329, 30-35 (2007)
B Lassalle et al.
Fertility and sterility, 44(5), 645-651 (1985-11-01)
Eighty-five human embryos fertilized in vitro were frozen and thawed with 1,2 propanediol as a cryoprotective agent. The effects of viability of in vitro culture duration, stage, and morphologic appearance of embryos were examined after thawing. Survival was higher for...
Gai Ling Li et al.
Journal of controlled release : official journal of the Controlled Release Society, 84(1-2), 49-57 (2002-10-26)
To achieve a therapeutical effect of the anti-Parkinson's drug R-apomorphine via iontophoresis delivery, enhancement strategies in vitro were explored using three structurally related enhancers, lauric acid (LA), dodecyltrimethylammonium bromide (DTAB) and Laureth-3 oxyethylene ether (C(12)EO(3)). Human stratum corneum and shed...
R S Rajasenan et al.
Toxicology and applied pharmacology, 135(1), 89-99 (1995-11-01)
Engrafting components of human immune systems in severe combined immunodeficient (SCID) mice has been utilized to investigate the pathogenesis of several human autoimmune diseases and may provide a model for studying idiosyncratic drug toxicity. The purpose of this investigation was...

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