85588

Spermine dihydrate

BioUltra, ≥99.5% (GC)

• Synonym(s): Gerontine, Musculamine, N,N′-Bis(3-aminopropyl)-1,4-diaminobutane, Neuridine
• Linear Formula: NH₂(CH₂)₃NH(CH₂)₄NH(CH₂)₃NH₂ · 2H₂O
• CAS Number: 403982-64-9
• Molecular Weight: 238.37
• Beilstein: 7526933
• Número EC: 200-754-2
• Número MDL: MFCD01459904
• ID de substância PubChem: 329769391
• NACRES: ND.02

Properties

• linha de produto: BioUltra
• Nível de qualidade: 100
• teor: ≥99.5% (GC)
• forma: powder
• Impurezas: insoluble matter, passes filter test
• pH: 12.0-13.5 (25 °C, 1 M in H₂O)
• pf: 63-64 °C
• solubilidade: H₂O: 1 M at 20 °C, clear, colorless
• traços de ânion: chloride (Cl^-): ≤50 mg/kg; sulfate (SO₄^2-): ≤50 mg/kg
• traços de cátion: Al: ≤5 mg/kg; As: ≤0.1 mg/kg; Ba: ≤5 mg/kg; Bi: ≤5 mg/kg; Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Li: ≤5 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Sr: ≤5 mg/kg; Zn: ≤5 mg/kg
• λ: 1 M in H₂O
• Absorção UV: λ: 260 nm A_max: 0.20; λ: 280 nm A_max: 0.20
• temperatura de armazenamento: 2-8°C
• SMILES string: O.O.NCCCNCCCCNCCCN
• InChI: 1S/C10H26N4.2H2O/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;/h13-14H,1-12H2;2*1H2
• InChI key: MTNRSMVAYLLBAV-UHFFFAOYSA-N

Description

Ações bioquímicas/fisiológicas

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Outras notas

Polyamines: Review[1]; Inhibitor of ATPase[2][3]; DNA polymerase[4]; ribonuclease[5]

Safety Information

• Pictogramas: GHS05
• Palavra indicadora: Danger
• Frases de perigo: H314
• Declarações de precaução: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Classificações de perigo: Skin Corr. 1B
• Código de classe de armazenamento: 8A - Combustible, corrosive hazardous materials
• WGK: WGK 3
• Ponto de fulgor (ºF): Not applicable
• Ponto de fulgor (ºC): Not applicable
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges