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D8284

Sigma-Aldrich

Bicinchoninic acid disodium salt hydrate

≥98% (HPLC)

Sinônimo(s):
Disodium 2,2′-biquinoline-4,4′-dicarboxylate, 4,4′-Dicarboxy-2,2′-biquinoline disodium salt, 2,2′-Biquinoline-4,4′-dicarboxylic acid disodium salt, BCA
Empirical Formula (Hill Notation):
C20H10N2Na2O4 · xH2O
Número CAS:
Peso molecular:
388.28 (anhydrous basis)
Número MDL:
ID de substância PubChem:
NACRES:
NA.47

Nível de qualidade

200

teor

≥98% (HPLC)

forma

powder

aplicação(ões)

hematology: suitable
histology: suitable

cor

white to light yellow

solubilidade

0.5% sodium bicarbonate: 50 mg/mL

Setor em destaque

Diagnostic Assay Manufacturing

temperatura de armazenamento

2-8°C

SMILES string

O.[Na+].[Na+].[O-]C(=O)c1cc(nc2ccccc12)-c3cc(C([O-])=O)c4ccccc4n3

InChI

1S/C20H12N2O4.2Na.H2O/c23-19(24)13-9-17(21-15-7-3-1-5-11(13)15)18-10-14(20(25)26)12-6-2-4-8-16(12)22-18;;;/h1-10H,(H,23,24)(H,25,26);;;1H2/q;2*+1;/p-2

InChI key

FAFVGCAYKZKOPT-UHFFFAOYSA-L

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Aplicação

  • Bicinchoninic acid disodium salt hydrate has been used to monitor the levels of reducing sugars, thereby helping in the detection of chitinases.
  • It has also been used to determine the amount of cellulose reducing ends (micromoles/g cellulose).
  • It has been used for determining protein concentration.

Embalagem

1, 5, 10, 25 g in poly bottle

Ações bioquímicas/fisiológicas

Bicinchoninic acid is used for the determination of protein concentration. It is responsible for the making of intense purple complex with cuprous ion (Cu+), in presence of alkaline conditions. The amount of Cu+ is in relation with the protein concentration.

Pictogramas

Exclamation mark

Palavra indicadora

Warning

Frases de perigo

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificado de análise

Certificado de origem

Detection and characterization of chitinases and other chitin-modifying enzymes.
Howard MB, et al.
Journal of Industrial Microbiology & Biotechnology, 30, 627-635 (2003)
Prevention of rt-PA induced blood-brain barrier component degradation by the poly(ADP-ribose)polymerase inhibitor PJ34 after ischemic stroke in mice.
Teng F, et al.
Experimental Neurology, 248, 416-428 (2013)
Makon-Sébastien Njock et al.
Blood, 125(20), 3202-3212 (2015-04-04)
The blood contains high concentrations of circulating extracellular vesicles (EVs), and their levels and contents are altered in several disease states, including cardiovascular disease. However, the function of circulating EVs, especially the microRNAs (miRNAs) that they contain, are poorly understood....
P K Smith et al.
Analytical biochemistry, 150(1), 76-85 (1985-10-01)
Bicinchoninic acid, sodium salt, is a stable, water-soluble compound capable of forming an intense purple complex with cuprous ion (Cu1+) in an alkaline environment. This reagent forms the basis of an analytical method capable of monitoring cuprous ion produced in...
Ramya Kumareswaran et al.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 116(3), 388-391 (2015-04-07)
Solid tumors contain regions of chronic and cyclic hypoxia. Chronic hypoxia can downregulate RAD51 and sensitize cells to PARP inhibition. Herein, we show that RAD51 expression, cell survival and toxicity to PARP inhibition is not affected under cyclic hypoxic conditions....

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