E4884

Ethylenediaminetetraacetic acid disodium salt dihydrate

ACS reagent, 99.0-101.0%

• Synonym(s): Disodium ethylenediaminetetraacetate dihydrate, EDTA disodium salt, EDTA-Na₂, Edathamil, Edetate disodium salt dihydrate, Sequestrene Na₂
• Empirical Formula (Hill Notation): C₁₀H₁₄N₂Na₂O₈ · 2H₂O
• CAS Number: 6381-92-6
• Molecular Weight: 372.24
• Beilstein: 3900609
• Número EC: 205-358-3
• ID de substância PubChem: 24894586
• NACRES: NA.77

Properties

• grau: ACS reagent
• Nível de qualidade: 200
• teor: 99.0-101.0%
• forma: solid
• Impurezas: ≤0.005% Insoluble matter; ≤0.1% Nitrilotriacetic acid ([HOCOCH₂]₃N)
• pH: 4.0-6.0 (25 °C, 5%)
• pf: 248 °C (dec.) (lit.)
• solubilidade: H₂O: 100 g/L at 20 °C
• traços de cátion: Fe: ≤0.01%; heavy metals: ≤0.005% (by ICP-OES)
• temperatura de armazenamento: room temp
• SMILES string: O.O.O.O.[Na+].[Na+].[Na+].[Na+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC(O)=O.OC(=O)CN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O
• InChI: 1S/C10H16N2O8.2Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;2*1H2/q;2*+1;;/p-2
• InChI key: OVBJJZOQPCKUOR-UHFFFAOYSA-L

Description

Descrição geral

EDTA is a chelator of divalent cations. It inhibits enzymes, such as metalloproteases, that require divalent cations for activity.

Aplicação

Ethylenediaminetetraacetic acid disodium salt dehydrate has been used as a component:

• of radioimmunoprecipitation assay buffer (RIPA buffer) for preparation of C2C12 mouse skeletal myoblasts whole cell lysate
• of lysis buffer and IgG resin wash and equilibration buffer for the purification of human proteasome regulatory particles (RPs)
• of M-buffer for the isolation of human cardiomyocyte progenitor cells (CMPCs) from fetal heart

Chelator of divalent cations. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.

Embalagem

100, 100, 500, 500 g

Ações bioquímicas/fisiológicas

Ethylenediaminetetraacetic acid (EDTA) is an anticoagulant, majorly used in preventing clotting of blood. EDTA may trigger aggregation of platelets resulting in pseudothrombocytopenia. EDTA along with tetracycline serves as a root conditioning agent and provides relief in gum infection. EDTA-tetracycline therapy decreases coronary artery calcium levels in atherosclerosis. Calcium disodium EDTA administration is effective in slowing down the progression of chronic kidney disease. It also enhances the antimicrobial functionality of lysozyme and improves shelf life of cheese.

Safety Information

• Pictogramas: GHS07,GHS08
• Palavra indicadora: Warning
• Frases de perigo: H332 - H373 - H412
• Declarações de precaução: P260 - P271 - P273 - P304 + P340 + P312 - P314 - P501
• Classificações de perigo: Acute Tox. 4 Inhalation - Aquatic Chronic 3 - STOT RE 2 Inhalation
• Órgãos-alvo: Respiratory Tract
• Código de classe de armazenamento: 11 - Combustible Solids
• WGK: WGK 2
• Ponto de fulgor (ºF): Not applicable
• Ponto de fulgor (ºC): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)