EDS

Sigma-Aldrich

Ethylenediaminetetraacetic acid

BioUltra, anhydrous, ≥99% (titration)

Sinônimo(s):
Edathamil, (Ethylenedinitrilo)tetraacetic acid, EDTA, Ethylenedinitrilotetraacetic acid
Fórmula linear:
(HO2CCH2)2NCH2CH2N(CH2CO2H)2
Número CAS:
Peso molecular:
292.24
Beilstein/REAXYS Number:
1716295
Número EC:
Número MDL:
eCl@ss:
39030907
ID de substância PubChem:
NACRES:
NA.77

Nível de qualidade

200

grau

anhydrous

linha de produto

BioUltra

teor

≥99% (titration)

forma

powder

pf

250 °C (dec.) (lit.)

solubilidade

water: soluble 0.4 g/L at 20 °C

SMILES string

OC(=O)CN(CCN(CC(O)=O)CC(O)=O)CC(O)=O

InChI

1S/C10H16N2O8/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20)

InChI key

KCXVZYZYPLLWCC-UHFFFAOYSA-N

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Descrição geral

Ethylenediaminetetraacetic acid (EDTA) is a substituted diamine and a versatile compound in household with industrial applications. EDTA chelates metal divalent cations like calcium, magnesium, zinc, copper, manganese by forming metal-EDTA complexes. It finds its application in cleaning products and detergent formulations. In paper and pulp industries, EDTA reduces the adverse effect of metal ions on bleaching. It functions as an antibacterial agent by removing calcium and magnesium divalent cations from the outer membrane and causes loss of lipopolysaccharide from the membrane, making the bacteria susceptible to bactericidal agents. Free EDTA has adverse effect on reproduction and development in mammals. EDTA can chelate ions from deposits that contribute to atherosclerosis, cancers and heart diseases. It can help to overcome cell membrane injury by reducing radical reactions and oxidation processes. It binds to calcium and reduces the risk of hypercalcinemia in cancer patients. Transmembrane ammonium EDTA gradient method aids in drug delivery, increasing drug retention and efficacy of therapeutics and lowers the cytotoxicity levels.

Aplicação

EDTA has been used:
  • as a medium supplement in embryo culture using synthetic oviduct fluid culture 1 (SOFC1) medium
  • in incubation of EpCAM+ cells with fluorescein isothiocyanate (FITC) conjugated antibody for cell sorting analysis
  • in pre-treatment of single cell suspension of dendritic cells from spleen for cell sorting with magnetic beads

Embalagem

1 kg in poly bottle
100, 500 g in poly bottle

Pictogramas

Exclamation mark

Palavra indicadora

Warning

Frases de perigo

Declarações de precaução

hazcat

Eye Irrit. 2

storage_class_code

11 - Combustible Solids

WGK Alemanha

WGK 2

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificado de análise

Certificado de origem

Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity
Menges M, et al.
The Journal of Experimental Medicine, 195(1), 15-22 (2002)
The application of EDTA in drug delivery systems: doxorubicin liposomes loaded via NH4EDTA gradient
Song Y, et al.
International journal of nanomedicine, 9, 3611-3621 (2014)
Effect of the absence or presence of various protein supplements on further development of bovine oocytes during in vitro maturation
Ali A and Sirard M
Biology of Reproduction, 66(4), 901-905 (2002)
The phenotypes of pluripotent human hepatic progenitors
Schmelzer E, et al.
Stem Cells, 24(8), 1852-1858 (2006)
EDTA: the chelating agent under environmental scrutiny
Oviedo C and Rodriguez J
Quimica nova, 26(6), 901-905 (2003)

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