Merck
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F6377

Sigma-Aldrich

Fluorescein sodium salt

used as fluorescent tracer

Sinônimo(s):
Sodium fluorescein, NaFl, Uranine, NaFluo, Acid Yellow 73, D&C;Yellow No. 8
Empirical Formula (Hill Notation):
C20H10Na2O5
Número CAS:
Peso molecular:
376.27
Número do índice de cores:
45350
Beilstein:
3833041
Número EC:
Número MDL:
ID de substância PubChem:
NACRES:
NA.47

Nível de qualidade

200

forma

powder

pH

8.3 (20 °C, 10 g/L)

pf

>300 °C

fluorescência

λex 460 nm; λem 515 nm(lit.)

application(s)

diagnostic assay manufacturing
hematology
histology

temperatura de armazenamento

room temp

SMILES string

[Na+].[Na+].[O-]c1ccc2c(Oc3cc([O-])ccc3C24OC(=O)c5ccccc45)c1

InChI

1S/C20H12O5.2Na/c21-11-5-7-15-17(9-11)24-18-10-12(22)6-8-16(18)20(15)14-4-2-1-3-13(14)19(23)25-20;;/h1-10,21-22H;;/q;2*+1/p-2

InChI key

RGPLGPBQJOQFJS-UHFFFAOYSA-L

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Descrição geral

Fluorescein is a xanthene dye and is a common labeling agent in biology.

Aplicação

Water soluble fluorescent dye used in permeability and vascular perfusion studies due to its small molecular radius. Sodium fluorescein is used as a fluorescent tracer to study blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) permeability in rodent models. The dye was used as a probe substrate in the study of organic anion transporting polypeptide (OATP) mediated drug transport in hepatocytes. Sodium fluorescein was also used to monitor in situ solute transportation into bone through fluorescence recovery after photobleaching (FRAP).
Fluorescein sodium salt has been used as a solute to study microvessel permeability. It has been used as a test molecule to study blood barrier penetration.

Embalagem

100, 500 g in glass bottle

Código de classe de armazenamento

11 - Combustible Solids

WGK

WGK 1

Ponto de fulgor (ºF)

423.7 °F - Pensky-Martens closed cup

Ponto de fulgor (ºC)

217.6 °C - Pensky-Martens closed cup

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificado de análise

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Temperature dependence of electronic parameters of organic Schottky diode based on fluorescein sodium salt.
Yahia IS, et al.
Synthetic Metals, 161(9), 881-887 (2011)
D Montermini et al.
The Journal of physiology, 543(Pt 3), 959-975 (2002-09-17)
The permeability, P(S), to sodium fluorescein (Stokes-Einstein radius = 0.45 nm) has been measured in single mesenteric capillaries of pithed frogs and anaesthetised rats as perfusion velocity, U, was varied over a range from 400 up to 2000-10,000 microm s(-1).
P Kozler et al.
Physiological research, 52(5), 607-614 (2003-10-11)
The aim was to study the blood-brain permeability according to the distribution in the rat brain of Evans blue (EB) and sodium fluorescein (NaFl) administered by an intracarotid injection. Eighteen animals were divided into six groups according to the state
The acute and chronic toxicity of two xanthene dyes, fluorescein sodium salt and phloxine B, to Daphnia pulex.
Walthall WK and Stark JD.
Environmental Pollution (Barking, Essex : 1987), 104(2), 207-215 (1999)
Dimitris N Xanthos et al.
Molecular pain, 8, 44-44 (2012-06-21)
Changes in the blood-central nervous system barriers occur under pathological conditions including inflammation and contribute to central manifestations of various diseases. After short-lasting peripheral and neurogenic inflammation, the evidence is mixed whether there are consistent blood-spinal cord changes. In the

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