IA00001

Colesterol

• Sinônimo(s): 3β-Hidroxi-5-colesteno, 5-Colesteno-3β-ol
• Fórmula empírica (Notação de Hill): C₂₇H₄₆O
• Número CAS: 57-88-5
• Peso molecular: 386.65
• Beilstein/REAXYS Number: 1915888
• MDL number: MFCD00003646

Propriedades

• InChI key: HVYWMOMLDIMFJA-DPAQBDIFSA-N
• InChI: 1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
• SMILES string: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
• biological source: synthetic
• assay: ≥98% (GC)
• form: powder
• packaging: pkg of 1 × 1 g IA00001-1G
• color: white to off-white
• bp: 360 °C (lit.)
• mp: 147-149 °C (lit.), 147-150
• solubility: ethanol: soluble, soluble
• density: 1.067 g/mL at 25 °C (lit.)
• shipped in: dry ice
• storage temp.: −20°C
• Quality Level: 300

Descrição

General description

Synthetic cholesterol has various applications in pharmaceutical research, including:

1.Drug Development: Cholesterol analogs are used in the development of drugs targeting cholesterol metabolism and related diseases such as atherosclerosis.

2.Biological Studies: Synthetic cholesterol is utilized to study the effects of cholesterol on cells, cellular processes, and as a standard in biological experiments.

3.Vaccine Development: It is used in the formulation of lipid-based adjuvants for vaccine development due to its ability to enhance immune responses.

4.Drug Delivery System Research: Cholesterol derivatives are incorporated into drug delivery systems to enhance the stability and bioavailability of pharmaceutical compounds.

5.Membrane Studies: Synthetic cholesterol is used to mimic the properties of cell membranes, aiding in the study of drug interactions and membrane permeability.

6.Disease Modeling: It is employed in disease modeling and in vitro studies to understand the role of cholesterol in various diseases.

Application

Advanced drug delivery

Biochem/physiol Actions

Componente importante de todas as membranas biológicas; cerca de 25% do teor total de lipídios no cérebro é de colesterol.

Features and Benefits

Research grade products that can easily be scaled to meets GMP needs.

Legal Information

SyntheChol is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Classe de armazenamento: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable