PHR1007

Supelco

Mannitol

Pharmaceutical Secondary Standard; Certified Reference Material

Sinônimo(s):
Mannite, D-Mannitol
Empirical Formula (Hill Notation):
C6H14O6
Número CAS:
Peso molecular:
182.17
Beilstein/REAXYS Number:
1721898
Número EC:
Número MDL:
ID de substância PubChem:
Número E:
E421
NACRES:
NA.24

Nível de qualidade

300

grau

certified reference material
pharmaceutical secondary standard

forma

neat

Certificado de análise (CofA)

current certificate can be downloaded

analyte chemical class(es)

oligosaccharides

aplicação(ões)

HPLC: suitable
gas chromatography (GC): suitable

pf

167-170 °C (lit.)

Setor em destaque

Cleaning Products
Cosmetics
Food and Beverages
Personal Care
Pharmaceutical (small molecule)

formato

neat

rastreabilidade da farmacopeia

traceable to PhEur M0200000
traceable to USP 1375105

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

InChI

1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1

InChI key

FBPFZTCFMRRESA-KVTDHHQDSA-N

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Descrição geral

Mannitol is an osmotic diuretic with a variety of clinical applications, one of which is the reduction of intracranial pressure. It is also found to be protective against ischemic and nephrotoxic acute renal failure.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicação

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Mannitol may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using capillary isotachophoresis technique.

Ações bioquímicas/fisiológicas

A sugar alcohol sweet tastant. Used in sweetness inhibition studies.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAB7668 in the slot below. This is an example certificate only and may not be the lot that you receive.

storage_class_code

11 - Combustible Solids

WGK Alemanha

WGK 1

Certificado de análise

Certificado de origem

Mannitol-induced acute renal failure
RHD, et al.
Medicine, 69(3), 153-159 (1990)
Mannitol
Warren ES and Blantz CR
Archives of Internal Medicine, 141(4), 493-497 (1981)
Separation and determination of pharmaceutically important polyols in dosage forms by capillary isotachophoresis
Pospisilova M, et al.
Journal of Chromatography A, 772(1-2), 277-282 (1997)
Heikki O Koskela et al.
Chest, 124(6), 2171-2177 (2003-12-11)
To compare a new bronchial provocation test, the mannitol challenge, with cold air and histamine challenges to demonstrate airway hyperresponsiveness (AHR) in patients with difficult-to-diagnose asthma. A prospective study. Thirty-seven consecutive patients with recently diagnosed, steroid-naive, mild, or atypical asthma...
Diana Bilton et al.
Thorax, 69(12), 1073-1079 (2014-09-24)
Bronchiectasis is characterised by excessive production of mucus and pulmonary exacerbations. Inhaled osmotic agents may enhance mucociliary clearance, but few long-term clinical trials have been conducted. To determine the impact of inhaled mannitol on exacerbation rates in patients with non-cystic...

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