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PHR1012

Supelco

Methylparaben

Pharmaceutical Secondary Standard; Certified Reference Material

Sinônimo(s):
Methyl 4-hydroxybenzoate, NIPAGIN, p-Hydroxybenzoic acid methyl ester, Methyl paraben
Fórmula linear:
HOC6H4CO2CH3
Número CAS:
Peso molecular:
152.15
Beilstein:
509801
Número EC:
Número MDL:
ID de substância PubChem:
Número E:
E218
NACRES:
NA.24

Nível de qualidade

300

grau

certified reference material
pharmaceutical secondary standard

Certificado de análise (CofA)

current certificate can be downloaded

aplicação(ões)

HPLC: suitable
gas chromatography (GC): suitable

pf

125-128 °C (lit.)

Setor em destaque

Cleaning Products
Cosmetics
Flavors and Fragrances
Food and Beverages
Personal Care
Pharmaceutical (small molecule)

formato

neat

rastreabilidade da farmacopeia

traceable to PhEur M1650000
traceable to USP 1432005

SMILES string

COC(=O)c1ccc(O)cc1

InChI

1S/C8H8O3/c1-11-8(10)6-2-4-7(9)5-3-6/h2-5,9H,1H3

InChI key

LXCFILQKKLGQFO-UHFFFAOYSA-N

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Descrição geral

Methylparaben is an antifungal and antibacterial agent, widely used as a preservative in cosmetics, pharmaceuticals, food and beverages.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicação

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Methylparaben may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using reversed-phase sequential injection chromatography (SIC) technique and high-performance liquid chromatography technique.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAC0280 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictogramas

Environment

Frases de perigo

Declarações de precaução

Hazard Classifications

Aquatic Chronic 2

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Ponto de fulgor (ºF)

334.4 °F

Ponto de fulgor (ºC)

168 °C

Certificado de análise

Certificado de origem

A novel gradient HPLC method for simultaneous determination of ranitidine, methylparaben and propylparaben in oral liquid pharmaceutical formulation
Kokoletsi XM, et al.
Journal of Pharmaceutical and Biomedical Analysis, 38(4), 763-767 (2005)
Determination of ambroxol hydrochloride, methylparaben and benzoic acid in pharmaceutical preparations based on sequential injection technique coupled with monolithic column
Satinsky D, et al.
Journal of Pharmaceutical and Biomedical Analysis, 40(2), 287-293 (2006)
Ismail I Hewala et al.
Talanta, 88, 623-630 (2012-01-24)
Simple methods for HPTLC peak purity assessment and identification of the HPTLC peaks were presented. The spectrodensitograms - selected at different time intervals across the elution time of the HPTLC peak - were extracted and digital algorithms for manipulating the...
Gabriela Oliveira et al.
International journal of pharmaceutics, 435(1), 38-49 (2012-05-29)
Simple topical formulations which include volatile components, such as gels or sprays, are appealing from a cosmetic perspective. However, complex formulation effects may result from the use of volatile excipients in topical formulations, particularly when applied at clinically relevant doses...
Simultaneous determination of methylparaben, propylparaben, hydrocortisone acetate and its degradation products in a topical cream by RP-HPLC.
Hajkova R, et al.
Journal of Pharmaceutical and Biomedical Analysis, 32(4-5), 921-927 (2003)

Protocolos

HPLC Analysis of Paraben Preservatives on Discovery® C18

Separation of Methyl Paraben, analytical standard; Ethylparaben, United States Pharmacopeia (USP) Reference Standard; Propylparaben, United States Pharmacopeia (USP) Reference Standard; Butylparaben, United States Pharmacopeia (USP) Reference Standard

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