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PHR1019

Supelco

Benzyl alcohol

Pharmaceutical Secondary Standard; Certified Reference Material

Sinônimo(s):
Benzenemethanol
Fórmula linear:
C6H5CH2OH
Número CAS:
Peso molecular:
108.14
Beilstein:
878307
Número EC:
Número MDL:
eCl@ss:
39023110
ID de substância PubChem:
NACRES:
NA.24

Nível de qualidade

300

grau

certified reference material
pharmaceutical secondary standard

densidade de vapor

3.7 (vs air)

pressão de vapor

13.3 mmHg ( 100 °C)
3.75 mmHg ( 77 °C)

Certificado de análise (CofA)

current certificate can be downloaded

temperatura de autoignição

817 °F

prazo de validade

~3 yr

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

índice de refração

n20/D 1.539 (lit.)

pb

203-205 °C (lit.)

pf

−16-−13 °C (lit.)

densidade

1.045 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

formato

neat

rastreabilidade da farmacopeia

traceable to PhEur Y0000167
traceable to USP 1061901

temperatura de armazenamento

2-30°C

SMILES string

OCc1ccccc1

InChI

1S/C7H8O/c8-6-7-4-2-1-3-5-7/h1-5,8H,6H2

InChI key

WVDDGKGOMKODPV-UHFFFAOYSA-N

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Descrição geral

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Benzyl alcohol is used as a preservative in pharmaceutical preparations in concentration up to 2% and as a solubilizer in concentrations of 5%. It is effective against gram-positive organisms.

Aplicação

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Benzyl alcohol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography and spectrophotometry.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAC1678 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictogramas

Exclamation mark

Palavra indicadora

Warning

Frases de perigo

Classificações de perigo

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2

Código de classe de armazenamento

10 - Combustible liquids

WGK

WGK 1

Ponto de fulgor (ºF)

213.8 °F - DIN 51758

Ponto de fulgor (ºC)

101 °C - DIN 51758

Certificado de análise

Certificado de origem

Simultaneous spectrophotometric determination of piroxicam and benzyl alcohol in gel forms.
Goger NG, et al.
Chem. Anal. (Warsaw), 50(6), 1059-1059 (2005)
Simultaneous spectrophotometric determination of benzyl alcohol and diclofenac in pharmaceuticals using methods based on the first derivative of the optical density ratio.
Ghasemi J, et al.
Pharmaceutical Chemistry Journal, 39(12) (2005)
Full spectrum and selected spectrum based multivariate calibration methods for simultaneous determination of betamethasone dipropionate, clotrimazole and benzyl alcohol: Development, validation and application on commercial dosage form.
Darwish HW, et al.
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 169, 50-57 (2016)
Simultaneous determination of bifonazole and benzyl alcohol in pharmaceutical formulations by reverse-phase HPLC.
Cudina OA, et al.
Chromatographia, 61(7-8), 415-418 (2005)
Kelly Roberta Francisco et al.
Langmuir : the ACS journal of surfaces and colloids, 28(41), 14531-14539 (2012-09-13)
Polymers formed by the self-assembly of a bis(urea)-based polymer, 2,4-bis(2-ethylhexylureido)toluene (EHUT), in organic solvents such as octane are promising systems with remarkable rheological properties. This is the first self-assembled polymer recently reported as a hydrodynamic drag reducer for hydrocarbons. The

Protocolos

US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on Equity®-5 (30 m x 0.25 mm I.D., 0.50 μm)

Chlorobenzilate; 4-Aminobiphenyl; 2-Fluorobiphenyl; N-Nitrosopyrrolidine; 1,2,4,5-Tetrachlorobenzene; 3-Methylcholanthrene; Phenacetin

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