Merck
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PHR1058

Supelco

Clotrimazole

Pharmaceutical Secondary Standard; Certified Reference Material

Sinônimo(s):
1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole, 1-(o-Chlorotrityl)imidazole, 1-(o-Chloro-α,α-diphenylbenzyl)imidazole
Empirical Formula (Hill Notation):
C22H17ClN2
Número CAS:
Peso molecular:
344.84
Número EC:
Número MDL:
ID de substância PubChem:
NACRES:
NA.24

Nível de qualidade

300

grau

certified reference material
pharmaceutical secondary standard

Agency

traceable to BP 379
traceable to Ph. Eur. C2430000
traceable to USP 1141002

Certificado de análise (CofA)

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

formato

neat

temperatura de armazenamento

2-30°C

SMILES string

Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4

InChI

1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H

InChI key

VNFPBHJOKIVQEB-UHFFFAOYSA-N

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Descrição geral

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Clotrimazole is an imidazole antifungal agent with relatively low toxicity. It is widely used in dermatology and gynaecology applications. Clotrimazole ointments are extensively utilized for the treatment of a wide range of systemic mycoses including candidiasis.

Aplicação

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Clotrimazole may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAA7129 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictogramas

Exclamation markEnvironment

Palavra indicadora

Warning

Classificações de perigo

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2

Código de classe de armazenamento

11 - Combustible Solids

WGK

WGK 3

Certificado de análise

Insira o número de lote para pesquisar o Certificado de análise (COA).

Certificado de origem

Insira o número de lote para pesquisar o Certificado de origem (COO).

Mais documentos

Quotes and Ordering

Development and validation of HPLC method for determination of clotrimazole and its two degradation products in spray formulation
Hajkova R, et al.
Talanta, 73(3), 483-489 (2007)
Determination of methylparaben, propylparaben, clotrimazole and its degradation products in topical cream by RP-HPLC
Solich P, et al.
Chromatographia, 56(1), S181-S184 (2002)
Chromatographic determination of clotrimazole, ketoconazole and fluconazole in pharmaceutical formulations
Abdel-Moety EM, et al.
Il Farmaco (Societa Chimica Italiana : 1989), 57(11), 931-938 (2002)
Sandra Gemma et al.
Journal of medicinal chemistry, 55(15), 6948-6967 (2012-07-13)
Despite recent progress in the fight against malaria, the emergence and spread of drug-resistant parasites remains a serious obstacle to the treatment of infections. We recently reported the development of a novel antimalarial drug that combines the 4-aminoquinoline pharmacophore of
Michael B McFerrin et al.
American journal of physiology. Cell physiology, 303(10), C1070-C1078 (2012-09-21)
An important event during apoptosis is regulated cell condensation known as apoptotic volume decrease (AVD). Ion channels have emerged as essential regulators of this process mediating the release of K(+) and Cl(-), which together with osmotically obliged water, results in

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