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PHR1204

Supelco

Benzophenone

Pharmaceutical Secondary Standard; Certified Reference Material

Sinônimo(s):
NSC 8077, Diphenylmethanone, Diphenyl ketone
Fórmula linear:
(C6H5)2CO
Número CAS:
Peso molecular:
182.22
Beilstein:
1238185
Número EC:
Número MDL:
ID de substância PubChem:
NACRES:
NA.24

Nível de qualidade

300

grau

certified reference material
pharmaceutical secondary standard

Agency

traceable to Ph. Eur. Y0000647

pressão de vapor

1 mmHg ( 108 °C)

Certificado de análise (CofA)

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

pb

305 °C (lit.)

pf

47-51 °C (lit.)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

formato

neat

temperatura de armazenamento

2-30°C

SMILES string

O=C(C1=CC=CC=C1)C2=CC=CC=C2

InChI

1S/C13H10O/c14-13(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H

InChI key

RWCCWEUUXYIKHB-UHFFFAOYSA-N

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Descrição geral

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Benzophenone is widely used in the manufacture of cosmetics and pharmaceuticals for its UV rays absorbing and fragrance retention abilities. Due to its ability to absorb ultraviolet radiations harmful in the form of UVA (320-400 nm) and UVB (290-320 nm), it is effective against skin disorders and skin cancer. It is used in the synthesis of antihistamines, hypnotics, and insecticides and is present as a potential impurity in diphenhydramine hydrochloride, phenytoin bulk powder, and phenytoin dosage forms.

Aplicação

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Benzophenone may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatographic, spectrophotometric and polarographic techniques.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAC3932 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictogramas

Health hazard

Palavra indicadora

Warning

Frases de perigo

Declarações de precaução

Classificações de perigo

Aquatic Chronic 3 - STOT RE 2 Oral

Código de classe de armazenamento

11 - Combustible Solids

WGK

WGK 1

Ponto de fulgor (ºF)

280.4 °F - closed cup

Ponto de fulgor (ºC)

138 °C - closed cup

Certificado de análise

Insira o número de lote para pesquisar o Certificado de análise (COA).

Certificado de origem

Insira o número de lote para pesquisar o Certificado de origem (COO).

Separation and simultaneous high-performance liquid chromatographic determination of benzocaine and benzyl benzoate in a pharmaceutical preparation
Gigante Barbara, et al.
Journal of Chromatography A, 549(1), 217-220 (1991)
Simultaneous analysis of benzophenone sunscreen compounds in water sample by stir bar sorptive extraction with in situ derivatization and thermal desorption-gas chromatography-mass spectrometry
Kawaguchi M, et al.
Journal of Chromatography A, 1200(2), 260-263 (2008)
Derivative spectrophotometric analysis of benzophenone (as an impurity) in phenytoin
Walash MI, et al.
Chemistry Central Journal, 5(1), 85-85 (2011)
Polarographic determination of phenytoin and benzophenone (as impurity) in pharmaceutical preparations
Razak OA, et al.
Journal of Pharmaceutical and Biomedical Analysis, 28(3-4), 613-619 (2002)
L L Barnkob et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 30(2), 395-402 (2012-11-17)
The aim of this study was to investigate the effect of relative humidity on the migration of benzophenone from paperboard into the food simulant Tenax®. Kinetic migration investigations were carried out with three relative humidities in the interval between 39%

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