PHR1526

Dexamethasone

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Dexamethasone, (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16α-methylprednisolone, Prednisolone F
• Empirical Formula (Hill Notation): C₂₂H₂₉FO₅
• CAS Number: 50-02-2
• Molecular Weight: 392.46
• Beilstein: 2066651
• Número EC: 200-003-9
• Número MDL: MFCD00064136
• ID de substância PubChem: 329823438
• NACRES: NA.24

Properties

• fonte biológica: synthetic
• Nível de qualidade: 300
• grau: certified reference material; pharmaceutical secondary standard
• Agency: BP; EP; USP; traceable to BP 578; traceable to Ph. Eur. D0700000; traceable to USP 1176007
• pressão de vapor: <0.0000001 kPa ( 25 °C)
• Certificado de análise (CofA): current certificate can be downloaded
• embalagem: pkg of 1 g
• condição de armazenamento: protect from light
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• cor: white
• pf: 262-264 °C (lit.)
• solubilidade: DMSO: soluble; acetone: sparingly soluble; chloroform: slightly soluble; dioxane: soluble; ethanol: sparingly soluble; ether: very slightly soluble; methanol: sparingly soluble; water: practically insoluble
• application(s): pharmaceutical (small molecule)
• formato: neat
• enviado em: ambient
• temperatura de armazenamento: 2-30°C
• SMILES string: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
• InChI: 1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
• InChI key: UREBDLICKHMUKA-CXSFZGCWSA-N
• Gene Information: human ... NR3C1(2908)

Description

Descrição geral

Dexamethasone is a corticosteroid medication, with anti-inflammatory activity. It is widely used for inflammatory ocular conditions and for the treatment of skin-allergic reactions.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicação

Dexamethasone may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using voltammentric techniques and reversed-phase high-performance liquid chromatography technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Ações bioquímicas/fisiológicas

Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAC2894 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• Pictogramas: GHS08
• Palavra indicadora: Danger
• Frases de perigo: H360FD
• Declarações de precaução: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classificações de perigo: Repr. 1B
• Código de classe de armazenamento: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Ponto de fulgor (ºF): Not applicable
• Ponto de fulgor (ºC): Not applicable