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Methylene Chloride

Pharmaceutical Secondary Standard; Certified Reference Material

Dichloromethane, Methylene chloride
Empirical Formula (Hill Notation):
Número CAS:
Peso molecular:
Número EC:
Número MDL:
ID de substância PubChem:

Nível de qualidade



certified reference material
pharmaceutical secondary standard


traceable to USP 1601441

densidade de vapor

2.9 (vs air)

pressão de vapor

24.45 psi ( 55 °C)
6.83 psi ( 20 °C)

Certificado de análise (CofA)

current certificate can be downloaded

temperatura de autoignição

1223 °F

Lim. expl.

22 %


ampule of 3x1.2 mL each


HPLC: suitable
gas chromatography (GC): suitable

índice de refração

n20/D 1.424 (lit.)


39.8-40 °C (lit.)


−97 °C (lit.)


1.325 g/mL at 25 °C (lit.)


pharmaceutical (small molecule)



temperatura de armazenamento


SMILES string




InChI key


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Descrição geral

Methylene chloride, also known as dichloromethane, is an organic solvent with widespread industrial applications.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.


These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Methylene Chloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by gas chromatography (GC) technique.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAB7796 in the slot below. This is an example certificate only and may not be the lot that you receive.


Exclamation markHealth hazard

Palavra indicadora


Classificações de perigo

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3


Central nervous system

Código de classe de armazenamento

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects



Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Certificado de análise

Insira o número de lote para pesquisar o Certificado de análise (COA).

Certificado de origem

Insira o número de lote para pesquisar o Certificado de origem (COO).

Methylene Chloride
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 5885-5885 (2018)
Accidental intoxication by dichloromethane at work place: Clinical case and literature review
Pacheco C, et al.
Journal of Acute Medicine, 6(2), 43-45 (2016)
Angharad M Roberts et al.
Science translational medicine, 7(270), 270ra6-270ra6 (2015-01-16)
The recent discovery of heterozygous human mutations that truncate full-length titin (TTN, an abundant structural, sensory, and signaling filament in muscle) as a common cause of end-stage dilated cardiomyopathy (DCM) promises new prospects for improving heart failure management. However, realization
K E Mauck et al.
Integrative and comparative biology, 54(2), 193-209 (2014-04-22)
Recent research suggests that plant viruses, and other pathogens, frequently alter host-plant phenotypes in ways that facilitate transmission by arthropod vectors. However, many viruses infect multiple hosts, raising questions about whether these pathogens are capable of inducing transmission-facilitating phenotypes in
Silvia K Moreno-Forero et al.
The ISME journal, 9(1), 150-165 (2014-06-18)
The efficacy of inoculation of single pure bacterial cultures into complex microbiomes, for example, in order to achieve increased pollutant degradation rates in contaminated material (that is, bioaugmentation), has been frustrated by insufficient knowledge on the behaviour of the inoculated


GC Analysis of Class 2 Residual Solvents on OVI-G43

GC Analysis of Class 2 Residual Solvents on OVI-G43

US EPA Method TO-17: GC Analysis of Volatiles on VOCOL® after Collection/Desorption using Air Toxics Tube

US EPA Method TO-17: GC Analysis of Volatiles on VOCOL® after Collection/Desorption using Air Toxics Tube

US EPA Method 8260: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap, Fast GC Analysis

US EPA Method 8260 describes the analysis of volatile organic compounds in solid wastes and ground waters. This application illustrates the analysis of many compounds commonly analyzed by this method using purge and trap coupled to GC-MS.

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