Merck
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RDD039

Sigma-Aldrich

Imidazole

for molecular biology, ≥99% (titration), free-flowing, Redi-Dri

Synonym(s):
1,3-Diaza-2,4-cyclopentadiene, Glyoxaline
Empirical Formula (Hill Notation):
C3H4N2
CAS Number:
Molecular Weight:
68.08
Beilstein:
103853
Número MDL:

grau

for molecular biology

Nível de qualidade

100

pressão de vapor

<1 mmHg ( 20 °C)

linha de produto

Redi-Dri

teor

≥99% (titration)

forma

crystalline powder

qualidade

free-flowing

pH

6.2-7.8 (25 °C)

pKa (25 °C)

6.95

pb

256 °C (lit.)

pf

88-91 °C (lit.)

application(s)

diagnostic assay manufacturing

atividade externa

DNase, RNase and protease, none detected

SMILES string

c1c[nH]cn1

InChI

1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5)

InChI key

RAXXELZNTBOGNW-UHFFFAOYSA-N

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Descrição geral

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.

Aplicação

Imidazole has been used
  • in the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein
  • in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography
  • as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells

Excellent for buffers in the range of pH 6.2-7.8

Ações bioquímicas/fisiológicas

Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).

Informações legais

Redi-Dri is a trademark of Sigma-Aldrich Co. LLC

Palavra indicadora

Danger

Frases de perigo

Classificações de perigo

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1B - Skin Corr. 1C

Código de classe de armazenamento

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Ponto de fulgor (ºF)

293.0 °F - closed cup

Ponto de fulgor (ºC)

145 °C - closed cup

Certificate of Analysis

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Certificate of Origin

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