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Y0000881

Ibuprofen for peak identification

European Pharmacopoeia (EP) Reference Standard

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Sinônimo(s):
Ibuprofen, α-Methyl-4-(isobutyl)phenylacetic acid, (±)-2-(4-Isobutylphenyl)propanoic acid
Empirical Formula (Hill Notation):
C13H18O2
Número CAS:
Peso molecular:
206.28
Número MDL:
ID de substância PubChem:
NACRES:
NA.24

grau

pharmaceutical primary standard

API family

ibuprofen

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

formato

neat

temperatura de armazenamento

−20°C

SMILES string

CC(C)Cc1ccc(cc1)C(C)C(O)=O

InChI

1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)

InChI key

HEFNNWSXXWATRW-UHFFFAOYSA-N

Gene Information

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Este Item
BP539PHR1004B1220000
Ibuprofen for peak identification European Pharmacopoeia (EP) Reference Standard

Y0000881

Ibuprofen for peak identification

Ibuprofen British Pharmacopoeia (BP) Reference Standard

BP539

Ibuprofen

Ibuprofen Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1004

Ibuprofen

vibrant-m

B1220000

Ibuprofen impurity B

manufacturer/tradename

EDQM

manufacturer/tradename

BP

manufacturer/tradename

-

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

format

neat

format

neat

format

neat

format

neat

API family

ibuprofen

API family

ibuprofen

API family

ibuprofen

API family

ibuprofen

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-30°C

storage temp.

-

Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, has been developed and issued under the Authority of the Issuing Pharmacopoeia.

For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia. Their suitability for any other use is not guaranteed and is the sole responsibility of the user. This standard is not intended for human or animal use.
Established for the preparation of reference solution (c) in testing for related substances and impurities in ibuprofen using liquid chromatography (General text 2.2.29), according to the monograph 0721 of European Pharmacopeia.

Ações bioquímicas/fisiológicas

Cyclooxygenase (COX) inhibitor that has greater activity against COX-1 than against COX-2.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

produto relacionado

Nº do produto
Descrição
Preços

Pictogramas

Exclamation mark

Palavra indicadora

Warning

Frases de perigo

Classificações de perigo

Acute Tox. 4 Oral - Eye Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

WGK

WGK 3


Certificates of Analysis (COA)

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Exemplo

T1503
Número do produto
-
25G
Tamanho/quantidade da embalagem

Exemplos adicionais:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

inserir como 1.000309185)

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  • Se encontrar um número de lote com um código de preenchimento, como 05427ES-021 - insira o número do lote 05427ES sem o código de preenchimento -021.

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PHR1933

Ibuprofen Impurity A

vibrant-m

BP557

4′-Isobutylacetophenone

Supelco

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PHR1934

Ibuprofen Impurity B

Ibuprofen sodium salt analytical standard, ≥98% (GC)

Supelco

I1892

Ibuprofen sodium salt

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PHR1146

Ibuprofen Related Compound C

Ibuprofen

Supelco

I110

Ibuprofen

Ibuprofen
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 2921-2923 (2017)
J B Whitlam et al.
Clinical pharmacology and therapeutics, 29(4), 487-492 (1981-04-01)
Free and total ibuprofen levels in serum and synovial fluid (SF) were determined in one male and 14 female arthritic patients (mean age 56 yr, range 19 to 77) after 400 mg three times daily for 2 days. Free drug
Bart Van Overmeire et al.
Lancet (London, England), 364(9449), 1945-1949 (2004-11-30)
Ibuprofen is used for treatment and prevention of patent ductus arteriosus in low-birthweight infants. Its effects on regional circulations differ from those of indometacin. Because prophylactic indometacin reduces the frequency of severe intraventricular haemorrhage and patent ductus arteriosus, we aimed
R O Day et al.
Clinical pharmacology and therapeutics, 43(5), 480-487 (1988-05-01)
The simultaneous disposition of the enantiomers of ibuprofen in synovial fluid and plasma was studied in eight patients with arthritis. Concentrations of the active S-enantiomer in synovial fluid exceeded those of the R-enantiomer at all times in all patients with
James F Markworth et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 305(11), R1281-R1296 (2013-10-04)
Classical proinflammatory eicosanoids, and more recently discovered lipid mediators with anti-inflammatory and proresolving bioactivity, exert a complex role in the initiation, control, and resolution of inflammation. Using a targeted lipidomics approach, we investigated circulating lipid mediator responses to resistance exercise

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