91707

Sigma-Aldrich

Trifluoroacetic acid

puriss. p.a., suitable for HPLC, ≥99.0% (GC)

Sinônimo(s):
TFA
Fórmula linear:
CF3COOH
Número CAS:
Peso molecular:
114.02
Beilstein/REAXYS Number:
742035
Número EC:
Número MDL:
ID de substância PubChem:
NACRES:
NA.21

Nível de qualidade

200

densidade de vapor

3.9 (vs air)

pressão de vapor

97.5 mmHg ( 20 °C)

grau

puriss. p.a.

teor

≥99.0% (GC)

forma

liquid

aplicação(ões)

HPLC: suitable
LC/MS: suitable

Impurezas

≤0.05% water

índice de refração

n20/D 1.3 (lit.)

pH

1 (20 °C, 1  g/L)

pb

72.4 °C (lit.)

pf

−15.4 °C (lit.)

solubilidade

water: soluble

densidade

1.489 g/mL at 20 °C (lit.)

λ

1 cm path, H2O reference

Absorção UV

λ: 260 nm Amax: 0.9
λ: 270 nm Amax: 0.1
λ: 280 nm Amax: 0.05
λ: 290 nm Amax: 0.04
λ: 300 nm Amax: 0.03
λ: 320 nm Amax: 0.025

adequação

corresponds to standard for RP gradient test

SMILES string

OC(C(F)(F)F)=O

InChI

1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7)

InChI key

DTQVDTLACAAQTR-UHFFFAOYSA-N

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Descrição geral

Trifluoroacetic acid (TFA) is a fluorinated acetic acid. It is widely used as trifluoromethylating reagent for trifluoromethylation of aromatic compounds.

Aplicação

Trifluoroacetic acid (TFA) may be used in the following studies:
  • Preparation of TFA reagent for the estimation of serum vitamin A.
  • To compose the binary solvent system for the isolation of large denatured peptides by reverse phase high performance liquid chromatography.
  • A mobile-phase additive for liquid chromatography-mass spectrometry (LC-MS) analysis.
  • Preparation of artemisinin under optimized reaction conditions.

Embalagem

package with 10x1mL

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Pictogramas

CorrosionExclamation mark

Palavra indicadora

Danger

Frases de perigo

hazcat

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A

storage_class_code

8A - Combustible, corrosive hazardous materials

WGK Alemanha

WGK 2

Ponto de fulgor (ºF)

212.0 °F - Pensky-Martens closed cup

Ponto de fulgor (ºC)

> 100 °C - Pensky-Martens closed cup

Certificado de análise

Certificado de origem

Guangfa Shi et al.
Organic letters, 17(1), 38-41 (2014-12-18)
Direct trifluoromethylation of arenes using TFA as the trifluoromethylating reagent was achieved with Ag as the catalyst. This reaction not only provides a new protocol for aryl C-H trifluoromethylation, but the generation of CF3· from TFA may prove useful in...
Risto Kostiainen et al.
Journal of chromatography. A, 1216(4), 685-699 (2008-09-19)
The most widely used ionization techniques in liquid chromatography-mass spectrometry (LC-MS) are electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI) and atmospheric pressure photoionization (APPI). All three provide user friendly coupling of LC to MS. Achieving optimal LC-MS conditions is...
Continuous-flow synthesis of the anti-malaria drug artemisinin.
François Lévesque et al.
Angewandte Chemie (International ed. in English), 51(7), 1706-1709 (2012-01-18)
W C Mahoney et al.
The Journal of biological chemistry, 255(23), 11199-11203 (1980-12-10)
A method employing reverse phase high performance liquid chromatography has been developed for the purification of large denatured peptides. The cyanogen bromide fragments of hemoglobin alpha, beta, and gamma chains (13 to 91 residues in length) could be separated and...
Macro- and micromethods for the determination of serum vitamin A using trifluoroacetic acid.
J B NEELD et al.
The Journal of nutrition, 79, 454-462 (1963-04-01)
Protocolos
Overcome challenges in synthesis and disulfide bond formation with protocols for Fmoc solid-phase peptide synthesis of peptides with cysteine and methionine.
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