Merck
Todas as fotos(3)

258024

Sigma-Aldrich

α-Tocopherol

≥95.5%

Sinônimo(s):
(±)-α-Tocopherol, Vitamin E, DL-all-rac-α-Tocopherol
Empirical Formula (Hill Notation):
C29H50O2
Número CAS:
Peso molecular:
430.71
Beilstein:
94012
Número EC:
Número MDL:
eCl@ss:
34058016
ID de substância PubChem:

Nível de qualidade

200

fonte biológica

synthetic

teor

≥95.5%

forma

liquid

technique(s)

HPLC: suitable

cor

faint brown to brown
yellow to very dark yellow

densidade

0.950 g/mL at 20 °C (lit.)

application(s)

cell analysis

temperatura de armazenamento

2-8°C

SMILES string

CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1

InChI

1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3

InChI key

GVJHHUAWPYXKBD-UHFFFAOYSA-N

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Descrição geral

α-Tocopherol is the active form of vitamin E. It functions as an hydroperoxyl radical scavenger and protects the organism from oxidative damage. α-Tocopherol plays a crucial role in cell signalling and regulating immune responses. α-Tocopherol deficiency is associated with abetalipoproteinemia, cystic fibrosis and celiac disease. It has antiproliferative effects. It inhibits arsenite-induced damage of human fibroblasts.

Aplicação

α-Tocopherol has been used:
  • as a standard to determine its concentration by reverse-phase high-performance liquid chromatography
  • to study its rescue effects on chlorine dioxide (ClO2) cytotoxicity
  • to assess its protective effects on acetaminophen (APAP)-mediated liver damage

Embalagem

5, 100, 500 g in glass bottle

Ações bioquímicas/fisiológicas

Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Various isofroms and analogues of tocopherol have opposing and differentiated regulatory activities in vivo.

Pictogramas

Exclamation mark

Palavra indicadora

Warning

Frases de perigo

Classificações de perigo

Skin Sens. 1

Código de classe de armazenamento

10 - Combustible liquids

WGK

WGK 1

Equipamento de proteção individual

Eyeshields, Gloves

Certificado de análise

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Certificado de origem

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Mais documentos

Quotes and Ordering

Effects of vitamin E on reproductive protection in pregnant mice infected with Pseudorabies Virus (PRV) via regulating expression of Toll-like receptors (TLRs) and cytokine balance
Wu D, et al.
Journal of nutritional science and vitaminology, 56(6), 353-363 (2010)
Glycosphingolipids Prevent APAP and HMG-CoA Reductase Inhibitors-mediated Liver Damage: A Novel Method for ?Safer Drug? Formulation that Prevents Drug-induced Liver Injury
Mizrahi M, et al.
Journal of clinical and translational hepatology, 6(2), 1-8 (2018)
Yang Wang et al.
PloS one, 10(8), e0135232-e0135232 (2015-08-15)
Ribavirin is used as a component of combination therapies for the treatment of chronic hepatitis C virus (HCV) infection together with pegylated interferon and/or direct-acting antiviral drugs. Its mechanism of action, however, is not clear. Direct antiviral activity and immunomodulatory
Early Diagnosis and Treatment of Cancer Series: Prostate Cancer E-Book: Expert Consult - Online and Print, 897-917 (2015)
Oxidative stress induced by chlorine dioxide as an insecticidal factor to the Indian meal moth, Plodia interpunctella
Kumar S, et al
Pesticide Biochemistry and Physiology, 124, 48-59 (2015)

Artigos

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

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