Todas as fotos(4)

30970

Sigma-Aldrich

Sodium deoxycholate

BioXtra, ≥98.0% (dry matter, NT)

Sinônimo(s):
Desoxycholic acid sodium salt, 3α,12α-Dihydroxy-5β-cholanic acid sodium salt, 7-Deoxycholic acid sodium salt
Empirical Formula (Hill Notation):
C24H39NaO4
Número CAS:
Peso molecular:
414.55
Beilstein:
3581950
Número EC:
Número MDL:
ID de substância PubChem:
NACRES:
NA.21

Nível de qualidade

300

fonte biológica

ox bile

descrição

anionic

linha de produto

BioXtra

teor

≥98.0% (dry matter, NT)

forma

powder

atividade óptica

[α]20/D +44±2°, c = 2% in H2O

peso molecular

micellar avg mol wt 1200-5000

número de agregação

3-12

technique(s)

DNA purification: suitable
RNA purification: suitable
electrophoresis: suitable

Impurezas

≤1% cholic acid (HPLC)
≤6% water

CMC

2-6 mM (20-25°C)

solubilidade

water: soluble 1 gm in 10 ml, clear, colorless to very faintly yellow

traços de cátion

Ca: ≤500 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤10 mg/kg
Mg: ≤10 mg/kg
Mn: ≤5 mg/kg
Ni: ≤5 mg/kg
Pb: ≤10 mg/kg
Zn: ≤5 mg/kg

HLB

16

grupo funcional

carboxylic acid

SMILES string

[Na+].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@H]([C@H](C)CCC([O-])=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2

InChI

1S/C24H40O4.Na/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3;/h14-21,25-26H,4-13H2,1-3H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-;/m1./s1

InChI key

FHHPUSMSKHSNKW-SMOYURAASA-M

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Aplicação

Sodium deoxycholate has been used for preparation of protein extracts for immunoblotting and immunoprecipitation of radiolabeled proteins.

Embalagem

25, 100, 500 g in poly bottle

Ações bioquímicas/fisiológicas

Sodium deoxycholate is a bile salt that stimulates the apical to basolateral accumulation of epirubicin in Caco-2 cells as well as increased serosal absorption of epirubicin in the rat jejunum and ileum. Sodium deoxycholate dissociates histones II from DNA as well as causes lysis of the viral membrane.

Pictogramas

Exclamation mark

Palavra indicadora

Warning

Frases de perigo

Declarações de precaução

Classificações de perigo

Acute Tox. 4 Oral - Aquatic Chronic 3

Código de classe de armazenamento

13 - Non Combustible Solids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificado de análise

Certificado de origem

Selective dissociation of histones from chromatin by sodium deoxycholate.
J E Smart et al.
Journal of molecular biology, 58(3), 651-659 (1971-06-28)
G Ramadori et al.
The Journal of experimental medicine, 162(3), 930-942 (1985-09-01)
During the acute phase response to tissue injury or inflammation, the concentration of several plasma proteins change. Previous work (29-34) suggested a role for interleukin 1 (IL-1) in the acute phase response. The availability of recombinant-generated mouse IL-1 prompted a
Y L Lo et al.
Biochemical pharmacology, 59(6), 665-672 (2000-02-25)
The effects of sodium deoxycholate (Deo-Na), a bile salt, and sodium caprate (Cap-Na), a fatty acid, on the transport of epirubicin were investigated in both the human colon adenocarcinoma (Caco-2) cell line and the everted gut sacs of the rat
A Helenius et al.
Biochimica et biophysica acta, 436(2), 319-334 (1976-06-17)
The effects of increasing concentrations of sodium deoxycholate on Semliki Forest have been studied. Sodium deoxycholate begins to bind to the virus at less than 0.1 mM free equilibrium concentration and causes lysis of the viral membrane at 0.9 +/-
Gang Chen et al.
Autophagy, 8(11), 1577-1589 (2012-08-10)
Ethanol is a neuroteratogen and neurodegeneration is the most devastating consequence of developmental exposure to ethanol. The mechanisms underlying ethanol-induced neurodegeneration are complex. Ethanol exposure produces reactive oxygen species (ROS) which cause oxidative stress in the brain. We hypothesized that

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