41639

Sigma-Aldrich

Dimethyl sulfoxide

BioUltra, for molecular biology, ≥99.5% (GC)

Sinônimo(s):
DMSO
Fórmula linear:
(CH3)2SO
Número CAS:
Peso molecular:
78.13
Beilstein/REAXYS Number:
506008
Número EC:
Número MDL:
ID de substância PubChem:
NACRES:
NA.25

Nível de qualidade

200

grau

for molecular biology

densidade de vapor

2.7 (vs air)

pressão de vapor

0.42 mmHg ( 20 °C)

linha de produto

BioUltra

teor

≥99.5% (GC)

forma

liquid

temperatura de autoignição

573 °F

Lim. expl.

42 %, 63 °F

Impurezas

Dnases, none detected
RNases, none detected
insoluble matter, passes filter test
phosphatases, none detected
proteases, none detected
≤0.001% free acid (as CH3COOH)

resíduo de evaporação

≤0.005%

cor

colorless

índice de refração

n20/D 1.479 (lit.)
n20/D 1.479

pb

189 °C (lit.)

pf

16-19 °C (lit.)

solubilidade

H2O: miscible (completely)

densidade

1.10 g/mL (lit.)

traços de cátion

Al: ≤0.5 mg/kg
Ba: ≤0.1 mg/kg
Bi: ≤0.1 mg/kg
Ca: ≤0.5 mg/kg
Cd: ≤0.05 mg/kg
Co: ≤0.02 mg/kg
Cr: ≤0.02 mg/kg
Cu: ≤0.02 mg/kg
Fe: ≤0.5 mg/kg
K: ≤0.5 mg/kg
Li: ≤0.1 mg/kg
Mg: ≤0.1 mg/kg
Mn: ≤0.02 mg/kg
Mo: ≤0.1 mg/kg
Na: ≤1 mg/kg
Ni: ≤0.5 mg/kg
Pb: ≤0.1 mg/kg
Sr: ≤0.1 mg/kg
Zn: ≤0.1 mg/kg

SMILES string

CS(C)=O

λ

neat

Absorção UV

λ: 280 nm Amax: 0.22

adequação

suitable for molecular biology

InChI

1S/C2H6OS/c1-4(2)3/h1-2H3

InChI key

IAZDPXIOMUYVGZ-UHFFFAOYSA-N

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Descrição geral

Dimethyl sulfoxide (DMSO) is an effective aprotic solvent. It is colorless, odorless and hygroscopic in nature. DMSO enhance the permeability of various hydrophilic and lipophilic permeants. It is one of the widely used solvents in the laboratory.

Aplicação

Dimethyl sulfoxide (DMSO) has been used as a vehicle for test compounds in various experimental studies. It has also been used as a solvent during amyloid β (Aβ) aggregation protocol for resolubilization of peptide to maintain its dissociated state.

Atenção

Supercools easily and remelts slowly at room temperature. Solidified product can be re-liquified by warming to room temperature without detriment to the product.

Outras notas

Polybrene / DMSO-assisted gene transfer

storage_class_code

10 - Combustible liquids

WGK Alemanha

WGK 1

Ponto de fulgor (ºF)

188.6 °F - closed cup

Ponto de fulgor (ºC)

87 °C - closed cup

Equipamento de proteção individual

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Certificado de análise

Certificado de origem

  1. What is the molarity of DMSO?

    DMSO will have a molarity of 14.1M, based on a density of 1.1 g/mL and a molecular weight of 78.13 g/mol.

  2. What is the DMSO dissolved in?

    DMSO is not dissolved in any solvent. It is a pure chemical compound that is a liquid at room temperature.

  3. Where does DMSO come from?

    DMSO is known to have been isolated from tree bark in the past. It is now a commericially synthesized solvent.

  4. Does DMSO have any synthetic utility?

    DMSO has been used to oxidize thiols and disulfides to sulfonic acids, hydrolysis of epoxides, thioalkylation of phenols, and oxidation of primary alcohols and halides, and esters of primary alcohols to aldehydes.

  5. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  6. Dimethyl sulfoxide (DMSO) should be a liquid.  Why did it arrive as a solid?

    DMSO supercools easily, and re-melts slowly at room temperature. The melting point is 16-19 °C. The solidified product can be re-liquefied by warming to room temperature without detriment to the product.

  7. What type of filter is used to sterile-filter Dimethyl sulfoxide (DMSO)?

    DMSO can be sterile-filtered through a 0.2 micron PTFE filter. The sterility testing is per the current US Pharmacopoeia method.

  8. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  9. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  10. What is Sure/Seal packaging?

    The Aldrich Sure/Seal packaging system is useful in the handling and storage of air-sensitive reagents.

Developmental toxicity assay using high content screening of zebrafish embryos
Lantz-McPeak S, et al.
Journal of Applied Toxicology, 35(3), 261-272 (2015)
Topical and Transdermal Drug Delivery
Handbook of non-invasive drug delivery systems: science and technology (2009)
R Aubin et al.
Methods in molecular biology (Clifton, N.J.), 7, 35-43 (1991-01-01)
Efforts to expand the current repertory of cell types amenable to transfection have often been thwarted by a common obstacle-namely, the low tolerance displayed by the recipient cells toward the gene-transfer regimen itself. As a result, several laboratories have turned...
The use of dimethylsulfoxide as a vehicle in cell culture experiments using ovarian carcinoma cell lines
Rodriguez-Burford C, et al.
Biotechniques, 78(1), 17-21 (2003)
Amyloid beta oligomers induce neuronal elasticity changes in age-dependent manner: a force spectroscopy study on living hippocampal neurons
Ungureanu A, et al.
Scientific reports, 6, 25841-25841 (2016)

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