The item is packaged in milligram quantities.
42602
Propionyl-L-carnitine
≥94.0% (HPLC), suitable for LC/MS
Sinônimo(s):
(2R)-3-Carboxy-N,N,N-trimethyl-2-(1-oxopropoxy)-1-propanaminium inner salt, L-Carnitine propionyl ester, C3-Carnitine, Propanoyl-L-carnitine
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Sobre este item
Fórmula empírica (Notação de Hill):
C10H19NO4
Número CAS:
Peso molecular:
217.26
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
MDL number:
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Estamos aqui para ajudarNome do produto
Propionyl-L-carnitine, ≥94.0% (HPLC)
SMILES string
[O-]C(C[C@@H](OC(CC)=O)C[N+](C)(C)C)=O
InChI
1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3/t8-/m1/s1
InChI key
UFAHZIUFPNSHSL-MRVPVSSYSA-N
assay
≥94.0% (HPLC)
form
powder or crystals
optical activity
[α]/D -23±3°, c = 1 in H2O
technique(s)
LC/MS: suitable
impurities
≤10% water (calcd. from elemental analysis)
color
white to off-white
storage temp.
2-8°C
Quality Level
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Este Item | |||
|---|---|---|---|
| form powder or crystals | form - | form - | form powder or crystals |
| technique(s) LC/MS: suitable | technique(s) - | technique(s) - | technique(s) - |
| assay ≥94.0% (HPLC) | assay ≥94.0% (HPLC) | assay ≥97.0% (HPLC) | assay ≥94.0% (HPLC) |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| optical activity [α]/D -23±3°, c = 1 in H2O | optical activity [α]/D -24.0±2.0°, c = 0.2 in H2O | optical activity [α]/D -17±2°, c = 1 in methanol | optical activity [α]/D -15±3°, c = 1 in H2O |
| impurities ≤10% water (calcd. from elemental analysis) | impurities ≤13% water ((calculated from elemental analysis) | impurities ≤10% water | impurities ≤10% water |
General description
Propionyl-L-carnitine (PLC) is a short-chain fatty acid ester derivative of carnitine.[1]
Application
Propionyl-L-carnitine has been used as a standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS).[2]
Biochem/physiol Actions
Propionyl-L-carnitine (PLC) plays a key role in lipid and carbohydrate metabolism. It provides substrates to the ischemic muscle for energy production and ATP generation.[1] PLC has the potential to treat severe peripheral arterial disease and chronic heart failure.[3] It is present in high abundance in the urine of patients with methylmalonyl-CoA mutase (MUT) deficiency, together with methylmalonic acid. MUT is a mitochondrial enzyme that catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA.
Classe de armazenamento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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William R Hiatt et al.
Journal of cardiopulmonary rehabilitation and prevention, 31(2), 125-132 (2010-09-24)
Exercise training is established for the treatment of peripheral artery disease; however the additional benefit of pharmacologic therapy with exercise has not been studied. This trial tested the hypothesis that propionyl-L-carnitine (PLC), in combination with monitored home-based exercise training, would
M J Cipolla et al.
Journal of vascular surgery, 29(6), 1097-1103 (1999-06-09)
The vasoactive effects of propionyl-L-carnitine (PLC) on human arteries, including endothelial and smooth muscle cell influences, were studied. Small (less than 200 microm) subcutaneous fat arteries (n = 19), obtained from human patients undergoing vascular surgery, were dissected and mounted
Carmen Mingorance et al.
Nutrition reviews, 69(5), 279-290 (2011-04-28)
Propionyl-L-carnitine (PLC) is a naturally occurring derivative of carnitine that plays an important role in the metabolism of both carbohydrates and lipids, leading to an increase of ATP generation. PLC, however, is not only a metabolic drug; it is also
Santica M Marcovina et al.
Translational research : the journal of laboratory and clinical medicine, 161(2), 73-84 (2012-11-10)
Mitochondria play important roles in human physiological processes, and therefore, their dysfunction can lead to a constellation of metabolic and nonmetabolic abnormalities such as a defect in mitochondrial gene expression, imbalance in fuel and energy homeostasis, impairment in oxidative phosphorylation
Qixiao Jiang et al.
Environmental toxicology and pharmacology, 48, 116-124 (2016-10-25)
Perfluorooctanoic acid (PFOA), a persistent organic pollutant, is associated with developmental toxicity. This study investigated the mechanism of PFOA-induced developmental cardiotoxicity in chicken embryo, focusing on the interactions between developmental exposure to PFOA and the levels of l-carnitine (LC), acetyl-l-carnitine
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