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Key Documents

51120

Sigma-Aldrich

Guanosine 5′-triphosphate sodium salt hydrate

≥90% (HPLC)

Sinônimo(s):

GTP, GTP-Na⁺ hydrate, 5′-GTP-Na2

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About This Item

Fórmula empírica (Notação de Hill):
C10H16N5O14P3 · xNa+ · yH2O
Número CAS:
Peso molecular:
523.18 (anhydrous free acid basis)
Beilstein:
4113439
Número CE:
Número MDL:
Código UNSPSC:
41106305
ID de substância PubChem:
NACRES:
NA.51

Ensaio

≥90% (HPLC)

forma

powder

atividade óptica

[α]20/D −24±2°, c = 1% in 0.5 M Na2HPO4

Impurezas

≤3 mol/mol water (NMR)

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

O.O.[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H16N5O14P3.2Na.2H2O/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);;;2*1H2/q;2*+1;;/p-2/t3-,5-,6-,9-;;;;/m1..../s1

chave InChI

HPLNHYUZFVUXFJ-ZVQJTLEUSA-L

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Descrição geral

Guanosine 5′-triphosphate (GTP) is a purine trinucleotide. GTP is a substrate for a wide range of G-protein coupled receptor (GPCR) GTPases, as well as cell signaling and cycling-associated guanine nucleotide exchange factors (GEF). See product G3776 for RNA polymerase transcription and DNA or RNA biosynthesis applications.

Aplicação

Guanosine 5′-triphosphate sodium salt hydrate has been used:
  • as a component of the internal solution for astrocyte patch-clamp to monitor astrocyte calcium activity from mouse amygdala slices.
  • in a solution for channel current recording in cell lines using a voltage-clamp technique.
  • to prepare internal recording solution for injectoporation to deliver genes to mechanosensory hair cells.
  • promoting the formation of G interface-mediated homodimers of human septin during the analysis of its oligomerization state by analytical size exclusion chromatography (SEC).

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type N95 (US)


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Gyu-Sang Hong et al.
Neuron, 94(2), 271-273 (2017-04-21)
Mechanosensation is essential for various physiological processes, and it is mediated by mechanotransduction channels. Recently, we reported that TMEM150C/Tentonin 3 (TTN3) confers mechanically activated currents with slow inactivation kinetics in several cell types, including dorsal root ganglion neurons (Hong et al.
Lukas Jakob Neukomm et al.
Development (Cambridge, England), 138(10), 2003-2014 (2011-04-15)
Multicellular organisms use programmed cell death to eliminate unwanted or potentially harmful cells. Improper cell corpse removal can lead to autoimmune diseases. The development of interventional therapies that increase engulfment activity could represent an attractive approach to treat such diseases.
J Spychala et al.
The International journal of biochemistry, 23(10), 1155-1159 (1991-01-01)
1. Phosphocellulose column chromatography under double gradient conditions (phosphate and KCl) revealed two forms of AMP deaminase in rat heart and brain and a single form in the liver and skeletal muscle. 2. Kinetically all purified AMP deaminases were classified
Wei Xiong et al.
Nature protocols, 9(10), 2438-2449 (2014-09-19)
Mechanosensation, the transduction of mechanical force into electrochemical signals, allows organisms to detect touch and sound, to register movement and gravity, and to sense changes in cell volume and shape. The hair cells of the mammalian inner ear are the
S P Gilbert et al.
Biochemistry, 32(17), 4677-4684 (1993-05-04)
The Drosophila kinesin heavy-chain gene was truncated to obtain the N-terminal 401 amino acid motor domain (designated K401) containing both the microtubule and ATP binding sites. The plasmid construct with the truncated kinesin gene was used to transform Escherichia coli.

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