Merck
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A2129

Sigma-Aldrich

γ-Aminobutyric acid

≥99%

Sinônimo(s):
3-Carboxypropylamine, GABA, Piperidinic acid, 4-Aminobutanoic acid, gamma-Aminobutyric acid, Piperidic acid
Fórmula linear:
NH2(CH2)3COOH
Número CAS:
Peso molecular:
103.12
Beilstein:
906818
Número EC:
Número MDL:
ID de substância PubChem:
NACRES:
NA.32

Nível de qualidade

200

teor

≥99%

forma

crystals

pf

195 °C (dec.) (lit.)

SMILES string

NCCCC(O)=O

InChI

1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)

InChI key

BTCSSZJGUNDROE-UHFFFAOYSA-N

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Aplicação

γ-Aminobutyric acid (GABA) has been used:
  • in the preparation of GABA–BSA (bovine serum albumin)–GA (glutaraldehyde) conjugate, which is used as a control for GABA immunostaining
  • in the macromolecule suppressed detection of GABA by magnetic resonance spectroscopy (MRS)
  • in the intraintestinal application of GABA in order to increase intraluminal fluid secretion

Ações bioquímicas/fisiológicas

GABA (γ-Aminobutyric acid) is an amino acid that functions as an inhibitory neurotransmitter in the central nervous system and also functions as a neuromodulator in some peripheral tissues. It binds to GABAA receptor and inhibits the activity of signal-receiving neurons. The GABAA receptors are found to form a channel in the cell membranes of neurons. Upon binding of GABA, the receptor is activated to allow the passage of negatively charged molecules, such as chloride ions, into the cell. This results in lowering of excitability of the cell.
GABAergic neurons are involved in myorelaxation, anxiolytic treatment, sedation, and anaesthetics. GABA can also influence heart rate and blood pressure.
Major inhibitory neurotransmitter in brain; GABAA and GABAB receptor agonist; increases Cl conductance.

Código de classe de armazenamento

11 - Combustible Solids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificado de análise

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Certificado de origem

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S J Mihic et al.
Alcohol health and research world, 21(2), 127-131 (1997-01-01)
The neurotransmitter gamma-aminobutyric acid (GABA) inhibits the activity of signal-receiving neurons by interacting with the GABAA receptor on these cells. The GABAA receptor is a channel-forming protein that allows the passage of chloride ions into the cells. Excessive GABAA activation
R Fabian-Fine et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(1), 298-310 (1998-12-31)
The mechanosensory organs of arachnids receive diverse peripheral inputs. Little is known about the origin, distribution, and function of these chemical synapses, which we examined in lyriform slit sense organ VS-3 of the spider Cupiennius salei. The cuticular slits of
Isabelle Niespodziany et al.
Epilepsia, 61(5), 914-923 (2020-04-17)
The antiepileptic drug candidate, padsevonil, is the first in a novel class of drugs designed to interact with both presynaptic and postsynaptic therapeutic targets: synaptic vesicle 2 proteins and γ-aminobutyric acid type A receptors (GABAA Rs), respectively. Functional aspects of
Richard A E Edden et al.
Magnetic resonance in medicine, 68(3), 657-661 (2012-07-11)
Edited magnetic resonance spectroscopy makes possible noninvasive studies of the role of the inhibitory neurotransmitter GABA in the healthy brain and in disease processes. A major limitation of the methodology is coediting of macromolecular signals. Although it has previously been
Bo Hjorth Bentzen et al.
Advances in pharmacological sciences, 2011, 578273-578273 (2011-12-14)
Intuitively one might expect that activation of GABAergic inhibitory neurons results in bradycardia. In conscious animals the opposite effect is however observed. GABAergic neurons in nucleus ambiguus hold the ability to control the activity of the parasympathetic vagus nerve that

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