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A3487

Sigma-Aldrich

Clarithromycin

96.0-102.0% (HPLC)

Empirical Formula (Hill Notation):
C38H69NO13
Número CAS:
Peso molecular:
747.95
Número MDL:
ID de substância PubChem:
NACRES:
NA.85

Nível de qualidade

200

fonte biológica

synthetic

teor

96.0-102.0% (HPLC)

forma

powder

cor

white to off-white

Modo de ação

protein synthesis | interferes

espectro de atividade do antibiótico

Gram-negative bacteria
Gram-positive bacteria

temperatura de armazenamento

2-8°C

SMILES string

O[C@@H]([C@@](O)(C)[C@@H](CC)OC([C@H](C)[C@H]1O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(OC)C2)=O)[C@@H](C)C([C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@H]1C)=O

InChI

1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1

InChI key

AGOYDEPGAOXOCK-KCBOHYOISA-N

Procurando produtos similares? Visit Guia de comparação de produtos

Categorias relacionadas

Aplicação

Clarithromycin has been used to study its effect on the potassium channel KCNJ5WT.

Ações bioquímicas/fisiológicas

Clarithromycin is stable in gastric acid.
Clarithromycin possess bactericidal activity including anti-mycobacterial activity against Mycobacterium leprae, and M.avium complex.
Clarithromycin is a macrolide antibiotic that interferes with bacterial protein synthesis. Clarithromycin is an acid-stable version of erythromycin and is particularly effective against Gram-negative bacteria. It has a short half-life, however its metabolite, 14-hydroxy clarithromycin is nearly twice as active as clarithromycin against certain bacteria.

Embalagem

100mg

Nota de preparo

Practically insoluble in water, soluble in acetone and methylene chloride, slightly soluble in methanol.

Outras notas

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Pictogramas

Exclamation mark

Palavra indicadora

Warning

Frases de perigo

Declarações de precaução

Classificações de perigo

Acute Tox. 4 Oral

Código de classe de armazenamento

11 - Combustible Solids

WGK

WGK 1

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Certificado de análise

Certificado de origem

Rui Chen et al.
Drug delivery, 24(1), 1191-1203 (2017-08-29)
Inhalation administration, compared with intravenous administration, significantly enhances chemotherapeutic drug exposure to the lung tissue and may increase the therapeutic effect for pulmonary anticancer. However, further identification of cancer cells after lung deposition of inhaled drugs is necessary to avoid
Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma
Scholl UI, et al.
The Journal of Clinical Investigation, 127(7), 2739-2750 (2017)
Leprosy
Antibiotic and chemotherapy e-book (2010)
Antituberculosis drugs
Antibiotic and chemotherapy e-book (2009)
Sonia Agudo et al.
Journal of clinical microbiology, 48(10), 3703-3707 (2010-07-30)
Clarithromycin is one of the antibiotics used for the treatment of Helicobacter pylori infections, and clarithromycin resistance is the most important factor when it comes to predicting eradication failure. The present study analyzed H. pylori isolates for the presence of

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