A4403

L-Ascorbic acid

powder, suitable for cell culture, γ-irradiated

• Synonym(s): L-Threoascorbic acid, Antiscorbutic factor, Vitamin C
• Empirical Formula (Hill Notation): C₆H₈O₆
• CAS Number: 50-81-7
• Molecular Weight: 176.12
• Beilstein: 84272
• Número EC: 200-066-2
• Número MDL: MFCD00064328
• ID de substância PubChem: 24890857
• NACRES: NA.75

Properties

• fonte biológica: synthetic (organic)
• Nível de qualidade: 200
• esterilidade: γ-irradiated
• forma: powder
• peso molecular: M_w 176.12 g/mol
• technique(s): cell culture | insect: suitable; cell culture | mammalian: suitable; cell culture | plant: suitable
• cor: white to off-white
• pH: 1.0-2.5 (25 °C, 176 g/L in water)
• pf: 190-194 °C (dec.)
• solubilidade: H₂O: 10 mg/mL
• SMILES string: OC([C@]([C@@H](O)CO)([H])O1)=C(O)C1=O
• InChI: 1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1
• InChI key: CIWBSHSKHKDKBQ-JLAZNSOCSA-N
• Gene Information: human ... SLC23A2(9962)

Description

Descrição geral

L-ascorbic acid is an unsaturated γ-lactone ring containing an enediol configuration (–COH=COH) attached with a carbonyl group.

Aplicação

For use in cell culture applications as an antioxidant and to regenerate tocopherol.
L-ascorbic acid has been used:

• in an osteogenic supplement for the growth of cells
• as a component in the differentiation media
• in WS-MSCs (Werner syndrome-mesenchymal stem cells) to study rescuing properties of ascorbic acid on aging defects

Ações bioquímicas/fisiológicas

L-ascorbic acid mainly exhibits antioxidant properties. It protects plants from oxidative stress and mammals from diseases associated with oxidative stress. L-ascorbic acid mainly protects from hydroxyl radicals, superoxide and singlet oxygen. In addition, it also reduces the membrane-linked antioxidant α-tocopherol (oxidised form). L-Ascorbic acid enhances endothelium-dependent vasodilation in various disorders, including diabetes, coronary artery disease, hypertension and chronic heart failure.

Safety Information

• Código de classe de armazenamento: 11 - Combustible Solids
• WGK: WGK 3
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)