Merck
All Photos(1)

A9525

Sigma-Aldrich

Angiotensin II human

≥93% (HPLC), powder

Synonym(s):
Ang II, Angiotensin 2, Angiotensin II, DRVYIHPF
Empirical Formula (Hill Notation):
C50H71N13O12
CAS Number:
Molecular Weight:
1046.18
eCl@ss:
42020611
ID de substância PubChem:
NACRES:
NA.32

fonte biológica

synthetic

Nível de qualidade

300

teor

≥93% (HPLC)

forma

powder

technique(s)

cell culture | mammalian: suitable

Impurezas

1.2-10.4% acetate

nº de adesão UniProt

temperatura de armazenamento

−20°C

InChI

1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41?/m0/s1

InChI key

CZGUSIXMZVURDU-GYGDIBSWSA-N

Gene Information

human ... AGT(183)

Amino Acid Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe

Aplicação

  • Angiotensin II (angII) human has been used to study its effect on interleukin-1β–mediated islet inflammation and β-cell dysfunction.[1]
  • It has been used to determine if angII activates specific calcineurin-dependent NFAT (nuclear factor of activated T-cells) isoforms in cardiomyocytes.[2]
  • It has been used to study the actions of systemic angII infusions on glomerular permeability in vivo.[3]
  • It has been used to check the effects of angII on plasma triglyceride production and its association with insulin resistance in normal rats.[4]

Ações bioquímicas/fisiológicas

Angiotensin II (angII) is an octapeptide hormone which affects the activities of heart, kidney, vasculature and brain. AngII in blood is produced from angiotensinogen via renin and angiotensin converting enzyme (ACE). It works via binding to specific receptors present on cell membranes. AngII is a component of the renin-angiotensin system. It is associated with vasoconstriction, induction of vascular smooth muscle cell growth, stimulation of protooncogene expression, modulation of myocardial hypertrophy, renal failure and fibrosis.[5][6][7][8][9][10]

Características e benefícios

The purity of our angiotensin II human, Ang II, is verified to assure your experimental success (HPLC and peptide content). The peptide sequence is DRVYIHPF.

Adsorvente de anticorpo

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH · 2CH3COOH · H2O

Nota de análise

Peptide content not less than 75%

Código de classe de armazenamento

13 - Non Combustible Solids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service