Merck
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A9650

Sigma-Aldrich

Angiotensin I human acetate salt hydrate

≥90% (HPLC)

Synonym(s):
Hypertensin I
Empirical Formula (Hill Notation):
C62H89N17O14 · xC2H4O2 · yH2O
CAS Number:
Molecular Weight:
1296.48 (anhydrous free base basis)
Número MDL:
eCl@ss:
42020611
ID de substância PubChem:
NACRES:
NA.32

Nível de qualidade

200

fonte biológica

human

teor

≥90% (HPLC)

forma

powder

peso molecular

1296 Da by calculation (Average Mass)

technique(s)

cell culture | mammalian: suitable

nº de adesão UniProt

temperatura de armazenamento

−20°C

SMILES string

CC(O)=O.CC(O)=O.CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@H](Cc5c[nH]cn5)C(=O)N[C@@H](CC(C)C)C(O)=O

InChI

1S/C62H89N17O14.2C2H4O2/c1-7-35(6)51(78-56(87)44(25-37-17-19-40(80)20-18-37)74-58(89)50(34(4)5)77-53(84)42(15-11-21-68-62(64)65)71-52(83)41(63)28-49(81)82)59(90)75-46(27-39-30-67-32-70-39)60(91)79-22-12-16-48(79)57(88)73-43(24-36-13-9-8-10-14-36)54(85)72-45(26-38-29-66-31-69-38)55(86)76-47(61(92)93)23-33(2)3;2*1-2(3)4/h8-10,13-14,17-20,29-35,41-48,50-51,80H,7,11-12,15-16,21-28,63H2,1-6H3,(H,66,69)(H,67,70)(H,71,83)(H,72,85)(H,73,88)(H,74,89)(H,75,90)(H,76,86)(H,77,84)(H,78,87)(H,81,82)(H,92,93)(H4,64,65,68);2*1H3,(H,3,4)/t35-,41-,42-,43-,44-,45+,46-,47-,48-,50-,51-;;/m0../s1

InChI key

CKIFOTYDIFUKEP-AUVUXLIHSA-N

Gene Information

human ... AGT(183)

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Amino Acid Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu

Descrição geral

Angiotensinogen (Angiotensin I) is a renin substrate, which is produced by the liver.

Aplicação

Angiotensin I human acetate salt hydrate has been used:
  • as an external calibration standard, it was applied to α-cyano-4-hydroxycinnamic acid (CHCA) and 2,5-dihydroxybenzoic acid (DHB) matrix,
  • to prepare angiotensin I solution gravimetrically for hydrolysis and also used as a model peptide to demonstrate SI (système international) -traceable amino acid analysis
  • as an analyte to deposit on the target in the study of on-line single droplet deposition for matrix-assisted laser desorption/ionization (MALDI) mass spectrometry

Ações bioquímicas/fisiológicas

Angiotensin I is a putative neurotransmitter. It is the precursor of angiotensin II and of angiotensin fragment 1-7, which are the hormones involved in regulation of fluid volume and the release of aldosterone.

Adsorvente de anticorpo

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH.2CH3COOH.6H2O

Código de classe de armazenamento

13 - Non Combustible Solids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificate of Analysis

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Certificate of Origin

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Product Information Sheet

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