Merck
All Photos(4)

B2515

Sigma-Aldrich

L-Buthionine-sulfoximine

≥97% (TLC)

Synonym(s):
L-BSO
Empirical Formula (Hill Notation):
C8H18N2O3S
CAS Number:
Molecular Weight:
222.31
Beilstein:
2367136
Número MDL:
ID de substância PubChem:
NACRES:
NA.77

fonte biológica

synthetic (organic)

Nível de qualidade

200

teor

≥97% (TLC)

forma

powder

pf

224-226  °C

solubilidade

water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

enviado em

wet ice

temperatura de armazenamento

−20°C

SMILES string

CCCCS(=N)(=O)CC[C@H](N)C(O)=O

InChI

1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1

InChI key

KJQFBVYMGADDTQ-CVSPRKDYSA-N

Gene Information

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Aplicação

L-Buthionine-sulfoximine has been used:
  • as a selective activator for the induction of ferroptosis in rat apoptotic cells
  • as an inhibitor of γ-glutamylcysteine synthetase to study its effects on the viability and effectiveness of microspore embryogenesis (ME) induction in triticale and barley
  • as a glutathione synthesis blocker to study its effects on auranofin (AFN)-mediated interleukin-1β expression in murine alveolar macrophages

Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.

Embalagem

500 mg in poly bottle
1, 5 g in poly bottle

Ações bioquímicas/fisiológicas

Blocks cellular resistance to chemotherapy by inhibiting γ-glutamylcysteine synthetase, a key enzyme in glutathione biosynthesis. Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.

Código de classe de armazenamento

13 - Non Combustible Solids

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificate of Analysis

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Certificate of Origin

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