B8686

(+)-N-3-Benzylnirvanol

≥98% (HPLC), powder

• Synonym(s): (5S)-5-Ethyl-5-phenyl-3-(phenylmethyl)-2,4-imidazolidinedione, 5-Ethyl-5-phenyl-3-(phenylmethyl)hydantoin
• Empirical Formula (Hill Notation): C₁₈H₁₈N₂O₂
• CAS Number: 790676-40-3
• Molecular Weight: 294.35
• Número MDL: MFCD09840024
• ID de substância PubChem: 329773138
• NACRES: NA.77

Properties

• Nível de qualidade: 100
• teor: ≥98% (HPLC)
• forma: powder
• solubilidade: DMSO: >20 mg/mL; H₂O: insoluble
• temperatura de armazenamento: 2-8°C
• SMILES string: CC[C@]1(NC(=O)N(Cc2ccccc2)C1=O)c3ccccc3
• InChI: 1S/C18H18N2O2/c1-2-18(15-11-7-4-8-12-15)16(21)20(17(22)19-18)13-14-9-5-3-6-10-14/h3-12H,2,13H2,1H3,(H,19,22)/t18-/m0/s1
• InChI key: ZMZDHUHMXXALFX-SFHVURJKSA-N

Description

Aplicação

(+)-N-3-Benzylnirvanol may be used as a cytochrome P450 2C19 (CYP2C19) inhibitor in a comparison study to treat cocktail and individual substrates for the screening for potent cytochrome P450 (CYP) inhibition. It may also be used in comparative studies to investigate its potential as CYP and non-CYP selective inhibitors of CYP2C19 in suspended human hepatocytes.

Embalagem

5, 10 mg in glass bottle

Ações bioquímicas/fisiológicas

(+)-N-3-Benzyl-nirvanol is a potent selective CYP2C19 inhibitor. CYP2C19 has a high frequency of drug resistance; highly polymorphic.

(+)-N-3-Benzylnirvanol serves as an inhibitor of cytochrome P450 2B6 (CYP2B6).

Safety Information

• Pictogramas: GHS07,GHS09
• Palavra indicadora: Warning
• Frases de perigo: H302 - H319 - H400
• Declarações de precaução: P264 - P270 - P273 - P280 - P301 + P312 - P305 + P351 + P338
• Classificações de perigo: Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2
• Código de classe de armazenamento: 11 - Combustible Solids
• WGK: WGK 3
• Ponto de fulgor (ºF): Not applicable
• Ponto de fulgor (ºC): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves