C3045

Sigma-Aldrich

Cholesterol

powder, BioReagent, suitable for cell culture, ≥99%

Sinônimo(s):
3β-Hydroxy-5-cholestene, 5-Cholesten-3β-ol
Empirical Formula (Hill Notation):
C27H46O
Número CAS:
Peso molecular:
386.65
Beilstein/REAXYS Number:
1915888
Número EC:
Número MDL:
eCl@ss:
39023139
ID de substância PubChem:
NACRES:
NA.75

Nível de qualidade

200

fonte biológica

ovine wool

linha de produto

BioReagent

teor

≥99%

forma

powder

aplicação(ões)

cell culture | mammalian: suitable

pb

360 °C (lit.)

pf

147-149 °C (lit.)

solubilidade

H2O: 0.002 mg/mL
Tween: soluble
ethanol: soluble
serum: soluble

densidade

1.067 g/mL at 25 °C (lit.)

enviado em

ambient

temperatura de armazenamento

−20°C

SMILES string

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

InChI key

HVYWMOMLDIMFJA-DPAQBDIFSA-N

Gene Information

Procurando produtos similares? Visit Guia de comparação de produtos

Categorias relacionadas

Descrição geral

Cholesterol, a major sterol is the precursor for steroid hormones, bile acid and vitamin in mammals and coordinates endocytosis. It complexes with protein to form lipoproteins for transport in blood. It exists either as high-density lipoprotein (HDL) or low-density lipoprotein (LDL). HDL also called good cholesterol has less lipid content. LDL or bad cholesterol has high lipid content. Statin inhibition of HMG-CoA reductase enzyme in the cholesterol biosynthesis pathway controls elevated cholesterol levels in atherosclerosis and hypercholesterolemia. Low levels of cholesterol results in hypothyroidism, familial hypobetalipoproteinemia and liver disease. Imbalance of cholesterol homeostasis and intracellular cholesterol levels play a key role in cancer development. High cholesterol levels favor breast cancer progression.

Aplicação

Cholesterol has been used:
  • as a medium supplement in chorionic villous tissue culture form placenta
  • as a component of hormone pellet for implantation in mice ovary
  • for inducing expression of immunity-related GTPase M (IRGM) in human monocytic cell line, THP-1

Embalagem

5, 25, 100 g in poly bottle

Ações bioquímicas/fisiológicas

Major component of all biological membranes; ~25% of total brain lipid is cholesterol.

storage_class_code

11 - Combustible Solids

WGK Alemanha

WGK 1

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificado de análise

Certificado de origem

The Crohn?s Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy
Mehto S, et al.
Molecular Cell (2019)
Patient-derived xenograft model for uterine leiomyoma by sub-renal capsule grafting
Serna VA and Kurita T
Journal of biological methods, 5(2), 84-94 (2018)
Impact of cholesterol on disease progression
Lin CJ, et al.
BioMedicine, 5(2) (2015)
The role of cholesterol in cancer
Kuzu OF, et al.
Cancer Research, 76(8), 2063-2070 (2016)
Role of cholesterol in the development and progression of breast cancer
Llaverias G et al.
The American Journal of Pathology, 178(1), 402-412 (2011)

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica