Merck
Todas as fotos(6)

C6506

Sigma-Aldrich

4-Chloro-DL-phenylalanine

greener alternative
Sinônimo(s):
PCP, PCPA
Fórmula linear:
ClC6H4CH2CH(NH2)CO2H
Número CAS:
Peso molecular:
199.63
Número EC:
Número MDL:
ID de substância PubChem:
NACRES:
NA.32

forma

solid

características do produto alternativo mais ecológico

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pf

>240 °C (dec.) (lit.)

categoria alternativa mais ecológica

Re-engineered

temperatura de armazenamento

room temp

SMILES string

NC(Cc1ccc(Cl)cc1)C(O)=O

InChI

1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)

InChI key

NIGWMJHCCYYCSF-UHFFFAOYSA-N

Gene Information

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Aplicação

4-Chloro-DL-phenylalanine has been used:
  • as tryptophan hydroxylase 1 (TPH1) inhibitor to treat kras+ male zebrafish
  • to induce insomnia in rat models
  • used to treat embryos to examine its effect on serotonin
  • for the selection of Enterococcus faecalis transformants with pESentA32 plasmid
  • to feed flies to explore serotonin effect

Embalagem

5, 25 g in poly bottle

Ações bioquímicas/fisiológicas

4-Chloro-DL-phenylalanine (PCPA) is an inhibitor of 5-hydroxytrytamine (5-HT) synthesis. It helps to improve the inflammation of lung tissue and remodeling pulmonary artery. PCPA can reduce the expression of tryptophan hydroxylase 1 (TPH1), matrix metalloproteinase (MMP) and pro-inflammatory factors.
Tryptophan hydroxylase inhibitor.

Pictogramas

Skull and crossbones

Palavra indicadora

Danger

Frases de perigo

Declarações de precaução

Classificações de perigo

Acute Tox. 3 Oral - Skin Sens. 1

Código de classe de armazenamento

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificado de análise

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Certificado de origem

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Dopamine and serotonin are both required for mate-copying in Drosophila melanogaster
Monier M, et al.
Frontiers in Behavioral Neuroscience, 12(5), 334-334 (2018)
Mariana G Fronza et al.
PloS one, 12(11), e0187445-e0187445 (2017-11-02)
A series of phenylselanyl-1H-1,2,3-triazole-4-carbonitriles with different substituents were screened for their binding affinity with serotonin transporter (SERT) and dopamine transporter (DAT) by docking molecular. 5-(4methoxyphenyl)-1-(2-(phenylselanyl)phenyl)-1H-1,2,3-triazole-4-carbonitrile (SeTACN) exhibited the best conformation with SERT even higher than fluoxetine and serotonin, suggesting a
In silico analysis and experimental validation of lignan extracts from kadsura longipedunculata for potential 5-HT1AR agonists
Zheng Y, et al.
PLoS ONE, 10(6), e0130055-e0130055 (2015)
Enhancement of the antibacterial activity of an E. faecalis strain by the heterologous expression of enterocin A
Serrano-Maldonado C E and Quirasco M
Journal of Biotechnology, 283(5), 28-36 (2018)
Marcin Leszczyński et al.
Science advances, 6(33), eabb0977-eabb0977 (2020-08-28)
Broadband high-frequency activity (BHA; 70 to 150 Hz), also known as "high gamma," a key analytic signal in human intracranial (electrocorticographic) recordings, is often assumed to reflect local neural firing [multiunit activity (MUA)]. As the precise physiological substrates of BHA

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