Merck
Todas as fotos(5)

D4902

Sigma-Aldrich

Dexamethasone

powder, BioReagent, suitable for cell culture, ≥97%

Todas as fotos(5)
Sinônimo(s):
9α-Fluoro-16α-methylprednisolone, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, Prednisolone F, (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
Empirical Formula (Hill Notation):
C22H29FO5
Número CAS:
50-02-2
Peso molecular:
392.46
Beilstein:
2066651
Número EC:
200-003-9
Número MDL:
MFCD00064136
ID de substância PubChem:
24893906
NACRES:
NA.75

Nível de qualidade

200

fonte biológica

synthetic

linha de produto

BioReagent

teor

≥97%

forma

powder

potência

4-500 ng/mL

technique(s)

cell culture | mammalian: suitable

pf

262-264 °C (lit.)

solubilidade

methanol: 25 mg/mL

enviado em

ambient

temperatura de armazenamento

2-8°C

SMILES string

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChI key

UREBDLICKHMUKA-CXSFZGCWSA-N

Gene Information

human ... ABCB1(5243) , CYP3A4(1576) , IL4(3565) , IL5(3567) , NR3C1(2908)
mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126) , Ptgs2(19225) , Tnf(21926)
rat ... Ar(24208) , Nr3c1(24413) , Tnf(24835)

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Categorias relacionadas

Aplicação

Dexamethasone is used to study apoptosis, cell signaling pathways, cell differentiation and gene expression.

Embalagem

25, 100, 500 mg in glass bottle
1 g in glass bottle
Bottomless glass bottle. Contents are inside inserted fused cone.

Ações bioquímicas/fisiológicas

Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.
It is poorly metabolized in the body and has great affinity and bioavailability.

forma física

powder 2-8 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw

Reconstituição

To prepare 20 μg/ml stock solution, add 1ml absolute ethanol per mg product; gently swirl to dissolve. Add 49 ml sterile medium per ml of ethanol added, while mixing, to acheive final concentration of 20 μg/ml.

Pictogramas

Health hazard
GHS08

Palavra indicadora

Danger

Frases de perigo

H360FD

Classificações de perigo

Repr. 1B

Código de classe de armazenamento

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Ponto de fulgor (ºF)

Not applicable

Ponto de fulgor (ºC)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificado de análise

Insira o número de lote para pesquisar o Certificado de análise (COA).

Certificado de origem

Insira o número de lote para pesquisar o Certificado de origem (COO).

Mais documentos

FT-NMR Spectra
Spectra - ATR-IR
Spectra for FT-IR Raman
Structure Search

Quotes and Ordering

Bulk Quote-Order Product

  1. What is Product D4902, Dexamethasone, soluble in?

    Dexamethasone is practically insoluble in water. It is soluble in ethanol, methanol, acetone, dioxane and slightly soluble in chloroform. 

  2. How should I reconstitute Product D4902, Dexamethasone, for tissue culture use?

    The tissue culture grade product is dissolved in ethanol at a concentration of 1 mg/ml forming a clear, colorless solution.  It is also possible to prepare a stock solution of dexamethasone in DMSO at 1.5 mM. 

  3. Do you have references for the use of Product D4902, Dexamethasone?

    References can be found on the product detail page:Migliorati, G., et al., Dexamethasone and interleukins modulate apoptosis of murine thymocytes and peripheral T-lymphocytes. Pharmacol Res., 30(1), 43-52 (1994).Bansal, N., et al., Apoptosis: mode of cell death induced in T cell leukemia lines by dexamethasone and other agents. FASEB J. 5(2), 211-6 (1991).Shiao, R.T., et al., Dexamethasone and suramin inhibit cell proliferation and interleukin-6-mediated immunoglobulin secretion in human lymphoid and multiple myeloma cell lines. Leuk. Lymphoma, 17(5-6), 485-494 (1995).Migliorati, G., et al, Dexamethasone induces apoptosis in mouse natural killer cells and cytotoxic T lymphocytes. Immunology, 81(1), 21-26 (1994).

  4. How long is Product D4902, Dexamethasone, stable in solution?

    Dexamethasone solutions are stable for at least 30 days when stored at 4 °C and protected from light. The solution may be aliquoted and stored at -20 °C. However, insufficient information is available to assess the shelf-life of the frozen solution.

  5. What cell lines has Product D4902, Dexamethasone, been tested on?

    The cell lines on which this product is tested can vary from lot to lot. Some typically used cell lines are 3T3 fibroblasts, BHK, L929 and CHO.

  6. What is the shelf life of Product D4902, Dexamethasone?

    The product has a 5 year shelf life.

  7. Product D4902, Dexamethasone is not water soluble. Do you have a water soluble Dexamethasone?

    Product D2915 is water soluble.

  8. Can I use Product D4902, Dexamethasone, to inject into mice?

    We do not perform animal studies with our products, but it can be used in cell culture (D2915 - cell culture grade version, or USP grade product D9184).

  9. Are Products D4902 and D2915, sterile?

    No. This product is not sterile, but cell culture testing did not find the product to be toxic to cells.

  10. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  11. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  12. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  13. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  14. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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